Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control

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Dallerac, Glenn ; Graupner, Michael ; Knippenberg, Jeroen ; Ruiz Martinez, Raquel Chacon ; Tavares, Tatiane Ferreira ; Tallot, Lucille ; El Massioui, Nicole ; Verschueren, Anna ; Hohn, Sophie ; Bertolus, Julie Boulanger ; Reyes, Alex ; LeDoux, Joseph E. ; Schafe, Glenn E. ; Diaz-Mataix, Lorenzo ; Doyere, Valerie

• Tipo de documento: Artigo Científico
• Fonte: NATURE COMMUNICATIONS; v. 8, JAN 9 2017.
• Citações Web of Science: 7

Resumo

Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala. (AU)

• Processo FAPESP: 12/06825-9 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva
• Beneficiário: Raquel Chacon Ruiz Martinez
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 14/22178-9 - O papel do erro de predição e da reconsolidação da memória no desencadeamento da plasticidade neural de núcleos da amígdala em um condicionamento apetitivo operante
• Beneficiário: Tatiane Ferreira Tavares
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 11/08575-7 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva
• Beneficiário: Raquel Chacon Ruiz Martinez
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores