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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control

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Dallerac, Glenn ; Graupner, Michael ; Knippenberg, Jeroen ; Ruiz Martinez, Raquel Chacon ; Tavares, Tatiane Ferreira ; Tallot, Lucille ; El Massioui, Nicole ; Verschueren, Anna ; Hohn, Sophie ; Bertolus, Julie Boulanger ; Reyes, Alex ; LeDoux, Joseph E. ; Schafe, Glenn E. ; Diaz-Mataix, Lorenzo ; Doyere, Valerie
Total Authors: 15
Document type: Journal article
Source: NATURE COMMUNICATIONS; v. 8, JAN 9 2017.
Web of Science Citations: 7
Abstract

Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala. (AU)

FAPESP's process: 12/06825-9 - The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response
Grantee:Raquel Chacon Ruiz Martinez
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 14/22178-9 - Role of temporal parameters and prediction error on triggering plasticity in amygdala nuclei and reconsolidation in an appetitive conditioning
Grantee:Tatiane Ferreira Tavares
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 11/08575-7 - The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response
Grantee:Raquel Chacon Ruiz Martinez
Support Opportunities: Research Grants - Young Investigators Grants