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The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response

Abstract

An important model for studying aversive learning is the two-way active avoidance model in which the learning is evaluated by the number of avoidance responses that occur in anticipation of the aversive stimulus (footshock). An important data is that there is a substantial number of animals (around 20%) that do not learning this task. Those animals failed in avoidance the aversive stimulus and show freezing response instead of the avoidance behavior. Related to the neural pathways responsible for the elaboration of active avoidance, many authors suggest the amygdala, specially the lateral nucleus of amygdala, as an important structure for this kind of learning and the dopamine as the possible neurotransmitter. In this sense, the role of the project is to evaluate the role of dopaminergic transmission in the lateral nucleus of amygdala during the two-way active avoidance test. Followed by the evaluation of the role of dopaminergic agonists: quinpirole (D2 agonist) and SKF 38393 (D1 agonist) in the lateral nucleus of amygdala in poor performers and dopaminergic antangonists: SCH 23390 (D1 antagonist) and sulpiride (D2 antagonist) in good performers and, finally, we will evaluate the release of dopamine in the lateral nucleus of amygdala using microdyalisis during the two-way active avoidance test in poor and good performers. (AU)

Scientific publications (13)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOUVEIA, FLAVIA VENETUCCI; GERMANN, JURGEN; DE MORAIS, ROSA; FONOFF, ERICH TALAMONI; HAMANI, CLEMENT; ALHO, EDUARDO JOAQUIM; BRENTANI, HELENA; MARTINS, ANA PAULA; DEVENYI, GABRIEL; PATEL, RAIHAAN; STEELE, CHRISTOPHER; GRAMER, ROBERT; CHAKRAVARTY, MALLAR; RUIZ MARTINEZ, RAQUEL CHACON. Longitudinal Changes After Amygdala Surgery for Intractable Aggressive Behavior: Clinical, Imaging Genetics, and Deformation-Based Morphometry Study-A Case Series. NEUROSURGERY, v. 88, n. 2, p. E158-E169, FEB 2021. Web of Science Citations: 0.
VAROTTO, BRUNA LUIZA ROIM; MARTINEZ, RAQUEL CHACON RUIZ; GOUVEIA, FLAVIA VENETUCCI; ANTUNES, GEIZA FERNANDA; FABRI, GISELE MARIA DE CAMPOS; BALLESTER, GERSON; ANTEQUERA, REYNALDO; DE SIQUEIRA, SILVIA REGINA DOWGAN TESSEROLI; FONOFF, ERICH TALAMONI; TEIXEIRA, MANOEL JACOBSEN; DE SIQUEIRA, JOSE TADEU TESSEROLI. Increased Anxiety-Like Behavior in the Acute Phase of a Preclinical Model of Periodontal Disease. FRONTIERS IN NEUROLOGY, v. 11, DEC 22 2020. Web of Science Citations: 0.
GOUVEIA, FLAVIA VENETUCCI; GERMANN, JUERGEN; DEVENYI, GABRIEL A.; MORAIS, ROSA M. C. B.; SANTOS, ANA PAULA M.; FONOFF, ERICH T.; HAMANI, CLEMENT; BRENTANI, HELENA; CHAKRAVARTY, M. MALLAR; MARTINEZ, RAQUEL C. R. Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder. BJPSYCH OPEN, v. 6, n. 5 SEP 2020. Web of Science Citations: 0.
ANTUNES, GEIZA FERNANDA; GOUVEIA, FLAVIA VENETUCCI; REZENDE, FABIANA STRAMBIO; DE JESUS SENO, MIDIA DIAS; DE CARVALHO, MILENE CRISTINA; DE OLIVEIRA, CAROLINE CRUZ; TOSATI DOS SANTOS, LENNON CARDOSO; DE CASTRO, MARINA CORREIA; KUROKI, MAYRA AKEMI; TEIXEIRA, MANOEL JACOBSEN; OTOCH, JOSE PINHATA; BRANDAO, MARCUS LIRA; FONOFF, ERICH TALAMONI; RUIZ MARTINEZ, RAQUEL CHACON. Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation. NEUROBIOLOGY OF STRESS, v. 12, MAY 2020. Web of Science Citations: 0.
DE ANDRADE, EMERSON MAGNO; MARTINEZ, RAQUEL C. R.; PAGANO, ROSANA L.; LOPES, PATRICIA S. S.; AUADA, ALINE V. V.; GOUVEIA, FLAVIA V.; ANTUNES, GEIZA F.; ASSIS, DANIELLE V.; LEBRUN, IVO; FONOFF, ERICH T. Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain. JOURNAL OF NEUROSURGERY, v. 132, n. 1, p. 239-251, JAN 2020. Web of Science Citations: 0.
GOUVEIA, FLAVIA VENETUCCI; HAMANI, CLEMENT; FONOFF, ERICH TALAMONI; BRENTANI, HELENA; LOPES ALHO, EDUARDO JOAQUIM; CAMPELO BORBA DE MORAIS, ROSA MAGALY; DE SOUZA, ALINE LUZ; RIGONATTI, SERGIO PAULO; MARTINEZ, RAQUEL C. R. Amygdala and Hypothalamus: Historical Overview With Focus on Aggression. NEUROSURGERY, v. 85, n. 1, p. 11-30, JUL 2019. Web of Science Citations: 1.
SENO, MIDIA D. J.; ASSIS, DANIELLE V.; GOUVEIA, FLAVIA; ANTUNES, GEIZA F.; KUROKI, MAYRA; OLIVEIRA, CAROLINE C.; SANTOS, LENNON C. T.; PAGANO, ROSANA L.; MARTINEZ, RAQUEL C. R. The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. SCIENTIFIC REPORTS, v. 8, SEP 11 2018. Web of Science Citations: 6.
MATSUMOTO, MARCIO; FLORES, EVA M.; KIMACHI, PEDRO P.; GOUVEIA, FLAVIA V.; KUROKI, MAYRA A.; BARROS, ALFREDO C. S. D.; SAMPAIO, MARCELO M. C.; ANDRADE, FELIPE E. M.; VALVERDE, JOAO; ABRANTES, EDUARDO F.; SIMOES, CLAUDIA M.; PAGANO, ROSANA L.; MARTINEZ, RAQUEL C. R. Benefits in radical mastectomy protocol: a randomized trial evaluating the use of regional anesthesia. SCIENTIFIC REPORTS, v. 8, MAY 18 2018. Web of Science Citations: 4.
DALLERAC, GLENN; GRAUPNER, MICHAEL; KNIPPENBERG, JEROEN; RUIZ MARTINEZ, RAQUEL CHACON; TAVARES, TATIANE FERREIRA; TALLOT, LUCILLE; EL MASSIOUI, NICOLE; VERSCHUEREN, ANNA; HOHN, SOPHIE; BERTOLUS, JULIE BOULANGER; REYES, ALEX; LEDOUX, JOSEPH E.; SCHAFE, GLENN E.; DIAZ-MATAIX, LORENZO; DOYERE, VALERIE. Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. NATURE COMMUNICATIONS, v. 8, JAN 9 2017. Web of Science Citations: 7.
DE OLIVEIRA, CAROLINE C.; GOUVEIA, FLAVIA V.; DE CASTRO, MARINA C.; KUROKI, MAYRA A.; DOS SANTOS, LENNON C. T.; FONOFF, ERICH T.; TEIXEIRA, MANOEL J.; OTOCH, JOSE P.; MARTINEZ, RAQUEL C. R. A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 10, AUG 24 2016. Web of Science Citations: 0.
FONOFF, ERICH TALAMONI; AZEVEDO, ANGELO; DOS ANGELOS, JAIRO SILVA; RUIZ MARTINEZ, RAQUEL CHACON; NAVARRO, JESSIE; REIS, PAUL RODRIGO; SAN MARTIN SEPULVEDA, MIGUEL ERNESTO; CURY, RUBENS GISBERT; DOS SANTOS GHILARDI, MARIA GABRIELA; TEIXEIRA, MANOEL JACOBSEN; CONTRERAS LOPEZ, WILLIAM OMAR. Simultaneous bilateral stereotactic procedure for deep brain stimulation implants: a significant step for reducing operation time. JOURNAL OF NEUROSURGERY, v. 125, n. 1, p. 85-89, JUL 2016. Web of Science Citations: 1.
CONTRERAS LOPEZ, W. O.; ANGELOS, J. S.; MARTINEZ, R. C. R.; TAKIMURA, C. K.; TEIXEIRA, M. J.; LEMOS NETO, P. A.; FONOFF, E. T. Optical coherence tomography imaging of the basal ganglia: feasibility and brief review. Brazilian Journal of Medical and Biological Research, v. 48, n. 12, p. 1156-1159, DEC 2015. Web of Science Citations: 3.
MARTINEZ, RAQUEL C. R.; GUPTA, NIKITA; LAZARO-MUNOZ, GABRIEL; SEARS, ROBERT M.; KIM, SOOJEONG; MOSCARELLO, JUSTIN M.; LEDOUX, JOSEPH E.; CAIN, CHRISTOPHER K. Active vs. reactive threat responding is associated with differential c-Fos expression in specific regions of amygdala and prefrontal cortex. LEARNING & MEMORY, v. 20, n. 8, p. 446-452, AUG 2013. Web of Science Citations: 35.

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