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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Amygdala and Hypothalamus: Historical Overview With Focus on Aggression

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Gouveia, Flavia Venetucci [1] ; Hamani, Clement [2, 3] ; Fonoff, Erich Talamoni [3] ; Brentani, Helena [4, 5] ; Lopes Alho, Eduardo Joaquim [3] ; Campelo Borba de Morais, Rosa Magaly [6] ; de Souza, Aline Luz [3] ; Rigonatti, Sergio Paulo [5] ; Martinez, Raquel C. R. [1]
Total Authors: 9
[1] Hosp Sirio Libanes, Lab Neurosci, Sao Paulo - Brazil
[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Neurosurg, Toronto, ON - Canada
[3] Univ Sao Paulo Sch, Med Sch, Inst Psychiat, Dept Neurol, Div Funct Neurosurg, Sao Paulo - Brazil
[4] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil
[5] Univ Sao Paulo, Med Sch, Dept Psychiat, Sao Paulo - Brazil
[6] Univ Sao Paulo, Dept Psychiat, PROTEA, Sch Med, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Review article
Source: NEUROSURGERY; v. 85, n. 1, p. 11-30, JUL 2019.
Web of Science Citations: 1

Aggressiveness has a high prevalence in psychiatric patients and is a major health problem. Two brain areas involved in the neural network of aggressive behavior are the amygdala and the hypothalamus. While pharmacological treatments are effective in most patients, some do not properly respond to conventional therapies and are considered medically refractory. In this population, surgical procedures (ie, stereotactic lesions and deep brain stimulation) have been performed in an attempt to improve symptomatology and quality of life. Clinical results obtained after surgery are difficult to interpret, and the mechanisms responsible for postoperative reductions in aggressive behavior are unknown. We review the rationale and neurobiological characteristics that may help to explain why functional neurosurgery has been proposed to control aggressive behavior. (AU)

FAPESP's process: 13/20602-5 - Prospective analyses of the functional results of philanthropist bilateral amygdalectomy in patients with refractory aggression
Grantee:Flavia Venetucci Gouveia
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/10466-8 - Towards revealing aggression: imaging the aggressive brain
Grantee:Flavia Venetucci Gouveia
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 11/08575-7 - The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response
Grantee:Raquel Chacon Ruiz Martinez
Support Opportunities: Research Grants - Young Investigators Grants