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Prospective analyses of the functional results of philanthropist bilateral amygdalectomy in patients with refractory aggression

Grant number: 13/20602-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2014
Effective date (End): April 14, 2018
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Raquel Chacon Ruiz Martinez
Grantee:Flavia Venetucci Gouveia
Host Institution: Hospital Sírio-Libanês. Sociedade Beneficente de Senhoras (SBSHSL). São Paulo , SP, Brazil
Associated research grant:11/08575-7 - The role of dopaminergic modulation in the lateral nucleus of amygdala during active avoidance response, AP.JP
Associated scholarship(s):17/10466-8 - Towards revealing aggression: imaging the aggressive brain, BE.EP.DR

Abstract

The aggressiveness is a heterogeneous behavior that has many facets and can be related to violence, impulsivity, irritability and hostility. The commonly applied treatment is the use of several medications. However, some individuals exhibit refractory aggression, considered a problem of public order whose only treatment recommended by competent organs and health inspectors is the realization of functional neurosurgical procedures. The amygdala is an important structure in controlling aggressive behavior, and the amygdalectomy leads to reduced aggressive behavior without other neurological or behavioral impairments in patients with pathological aggression disorder. In this project, patients will be submitted to amygdalectomy procedure as approved by the local medical council (Conselho Regional Medical do Estado de São Paulo). This procedure consists in the lesion of the amygdalar complex by radiofrequency under stereotactic guidance, with is considered consecrated method worldwide and in our work environment. On the occasion of the lesion, material for analysis of biochemical content will be collected and the registration of neuronal electrical activity will be performed. Also, images of the patient's encephalon will be made in a Magnetic Resonance device for posterior analyses of the anatomical structures. Thus, the project aims to assess functional results of surgical intervention and information about patients with refractory aggressive disorder, using the neuroimaging, clinical evaluation, neurochemistry and electrophysiology. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOUVEIA, FLAVIA VENETUCCI; GERMANN, JUERGEN; DEVENYI, GABRIEL A.; MORAIS, ROSA M. C. B.; SANTOS, ANA PAULA M.; FONOFF, ERICH T.; HAMANI, CLEMENT; BRENTANI, HELENA; CHAKRAVARTY, M. MALLAR; MARTINEZ, RAQUEL C. R.. Refractoriness of aggressive behaviour to pharmacological treatment: cortical thickness analysis in autism spectrum disorder. BJPSYCH OPEN, v. 6, n. 5, . (13/20602-5, 11/08575-7, 17/10466-8)
SENO, MIDIA D. J.; ASSIS, DANIELLE V.; GOUVEIA, FLAVIA; ANTUNES, GEIZA F.; KUROKI, MAYRA; OLIVEIRA, CAROLINE C.; SANTOS, LENNON C. T.; PAGANO, ROSANA L.; MARTINEZ, RAQUEL C. R.. The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. SCIENTIFIC REPORTS, v. 8, . (15/26079-8, 11/08575-7, 14/12999-5, 13/20602-5)
GOUVEIA, FLAVIA VENETUCCI; GERMANN, JURGEN; DE MORAIS, ROSA; FONOFF, ERICH TALAMONI; HAMANI, CLEMENT; ALHO, EDUARDO JOAQUIM; BRENTANI, HELENA; MARTINS, ANA PAULA; DEVENYI, GABRIEL; PATEL, RAIHAAN; et al. Longitudinal Changes After Amygdala Surgery for Intractable Aggressive Behavior: Clinical, Imaging Genetics, and Deformation-Based Morphometry Study-A Case Series. NEUROSURGERY, v. 88, n. 2, p. E158-E169, . (13/20602-5, 17/10466-8, 11/08575-7)
GOUVEIA, FLAVIA VENETUCCI; GERMANN, JURGEN; OLIVEIRA, CAROLINE C.; CASTRO, MARINA C.; ANTUNES, GEIZA F.; GOMES, V, GISELE C.; PINTO, TAIS R. C.; MARTINEZ, RAQUEL C. R.; VALLE, ANGELA C.. Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy. Neuroscience, v. 480, p. 32-41, . (11/08575-7, 17/10466-8, 13/20602-5)
VAROTTO, BRUNA LUIZA ROIM; MARTINEZ, RAQUEL CHACON RUIZ; GOUVEIA, FLAVIA VENETUCCI; ANTUNES, GEIZA FERNANDA; FABRI, GISELE MARIA DE CAMPOS; BALLESTER, GERSON; ANTEQUERA, REYNALDO; DE SIQUEIRA, SILVIA REGINA DOWGAN TESSEROLI; FONOFF, ERICH TALAMONI; TEIXEIRA, MANOEL JACOBSEN; et al. Increased Anxiety-Like Behavior in the Acute Phase of a Preclinical Model of Periodontal Disease. FRONTIERS IN NEUROLOGY, v. 11, . (11/08575-7, 13/20602-5)
DE OLIVEIRA, CAROLINE C.; GOUVEIA, FLAVIA V.; DE CASTRO, MARINA C.; KUROKI, MAYRA A.; DOS SANTOS, LENNON C. T.; FONOFF, ERICH T.; TEIXEIRA, MANOEL J.; OTOCH, JOSE P.; MARTINEZ, RAQUEL C. R.. A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 10, . (11/08575-7, 14/12999-5, 13/20602-5)
GOUVEIA, FLAVIA VENETUCCI; HAMANI, CLEMENT; FONOFF, ERICH TALAMONI; BRENTANI, HELENA; LOPES ALHO, EDUARDO JOAQUIM; CAMPELO BORBA DE MORAIS, ROSA MAGALY; DE SOUZA, ALINE LUZ; RIGONATTI, SERGIO PAULO; MARTINEZ, RAQUEL C. R.. Amygdala and Hypothalamus: Historical Overview With Focus on Aggression. NEUROSURGERY, v. 85, n. 1, p. 11-30, . (13/20602-5, 17/10466-8, 11/08575-7)
ANTUNES, GEIZA FERNANDA; GOUVEIA, FLAVIA VENETUCCI; REZENDE, FABIANA STRAMBIO; DE JESUS SENO, MIDIA DIAS; DE CARVALHO, MILENE CRISTINA; DE OLIVEIRA, CAROLINE CRUZ; TOSATI DOS SANTOS, LENNON CARDOSO; DE CASTRO, MARINA CORREIA; KUROKI, MAYRA AKEMI; TEIXEIRA, MANOEL JACOBSEN; et al. Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation. NEUROBIOLOGY OF STRESS, v. 12, . (17/10466-8, 13/20602-5, 11/08575-7, 14/12999-5)
MATSUMOTO, MARCIO; FLORES, EVA M.; KIMACHI, PEDRO P.; GOUVEIA, FLAVIA V.; KUROKI, MAYRA A.; BARROS, ALFREDO C. S. D.; SAMPAIO, MARCELO M. C.; ANDRADE, FELIPE E. M.; VALVERDE, JOAO; ABRANTES, EDUARDO F.; et al. Benefits in radical mastectomy protocol: a randomized trial evaluating the use of regional anesthesia. SCIENTIFIC REPORTS, v. 8, . (13/20602-5, 15/26079-8, 11/08575-7)
GOUVEIA, FLAVIA VENETUCCI; GERMANN, JURGEN; DEVENYI, GABRIEL A.; FONOFF, ERICH T.; MORAIS, ROSA M. C. B.; BRENTANI, HELENA; CHAKRAVARTY, M. MALLAR; MARTINEZ, RAQUEL C. R.. Bilateral Amygdala Radio-Frequency Ablation for Refractory Aggressive Behavior Alters Local Cortical Thickness to a Pattern Found in Non-refractory Patients. FRONTIERS IN HUMAN NEUROSCIENCE, v. 15, . (13/20602-5, 11/08575-7, 17/10466-8)

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