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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Arginine intake is associated with oxidative stress in a general population

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Autor(es):
de Carvalho, Aline Martins ; Falcao de Oliveira, Antonio Anax ; de Melo Loureiro, Ana Paula ; Figaro Gattas, Gilka Jorge ; Fisberg, Regina Mara ; Marchioni, Dirce Maria
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: NUTRITION; v. 33, p. 211-215, JAN 2017.
Citações Web of Science: 3
Resumo

Objective: The aim of this study was to assess the association between protein and arginine from meat intake and oxidative stress in a general population. Methods: Data came from the Health Survey for Sao Paulo (ISA-Capital), a cross-sectional population based study in Brazil (N = 549 adults). Food intake was estimated by a 24-h dietary recall. Oxidative stress was estimated by malondialdehyde (MDA) concentration in plasma. Analyses were performed using general linear regression models adjusted for some genetic, lifestyle, and biochemical confounders. Results: MDA levels were associated with meat intake (P for linear trend = 0.031), protein from meat (P for linear trend = 0.006), and arginine from meat (P for linear trend = 0.044) after adjustments for confounders: age, sex, body mass index, smoking, physical activity, intake of fruit and vegetables, energy and heterocyclic amines, C-reactive protein levels, and polymorphisms in GSTM1 (glutathione S-transferase Mu 1) and GSTT1 (glutathione S-transferase theta 1) genes. Results were not significant for total protein and protein from vegetable intake (P > 0.05). Conclusions: High protein and arginine from meat intake were associated with oxidative stress independently of genetic, lifestyle, and biochemical confounders in a population-based study. Our results suggested a novel link between high protein/arginine intake and oxidative stress, which is a major cause of age -related diseases. (C) 2016 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 09/15831-0 - Fatores dietéticos, homocisteína, polimorfismos do gene MTHFR e risco cardiovascular em adultos e idosos: estudo de base populacional - ISA - capital
Beneficiário:Regina Mara Fisberg
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/04607-0 - Relação entre consumo de carne e aminas heterocíclicas e marcadores bioquímicos e genéticos
Beneficiário:Aline Martins de Carvalho
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 12/10965-0 - Consumo de carnes e aminas heterocíclicas e sua relação com biomarcadores de exposição e suscetibilidade para câncer no estudo ISA-Capital
Beneficiário:Aline Martins de Carvalho
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/08617-4 - Variáveis no controle glicêmico e patogênese da nefropatia diabética: investigação sobre o fenômeno da memória metabólica
Beneficiário:Antonio Anáx Falcão de Oliveira
Linha de fomento: Bolsas no Brasil - Doutorado Direto