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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

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Autor(es):
Machado, Ricardo Borges ; Suchecki, Deborah
Número total de Autores: 2
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN ENDOCRINOLOGY; v. 7, DEC 23 2016.
Citações Web of Science: 1
Resumo

Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review. (AU)

Processo FAPESP: 10/09087-3 - O papel da prolactina no rebote de sono paradoxal induzido pelo estresse
Beneficiário:Ricardo Borges Machado
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 15/26364-4 - Mecanismos neurobiológicos envolvidos nas consequências emocionais tardias da privação maternal
Beneficiário:Deborah Suchecki
Linha de fomento: Auxílio à Pesquisa - Regular