Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

Author(s)

Machado, Ricardo Borges ; Suchecki, Deborah

• Document type: Review article
• Source: FRONTIERS IN ENDOCRINOLOGY; v. 7, DEC 23 2016.
• Web of Science Citations: 1

Abstract

Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH (18-39)) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review. (AU)

• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 15/26364-4 - Neurobiologic mechanisms involved in the long-term emotional effects of maternal deprivation
• Grantee: Deborah Suchecki
• Support Opportunities: Regular Research Grants