Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships

• Grant number: 09/51886-3
• Support type: Research Projects - Thematic Grants
• Duration: February 01, 2010 - January 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology
• Principal researcher: João Palermo Neto
• Grantee: João Palermo Neto
• Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Principal researchers: Frederico Azevedo da Costa Pinto
• Associated scholarship(s): 14/24395-7 - In vitro effects of noradrenaline and corticosterone on the activity of macrophages and T lymphocytes of SPF chickens, BP.IC; 13/18921-5 - Effects of modafinil on immunity, neuroinflammation and development of experimental autoimmune encephalomyelitis in mice, BP.PD; 13/17408-2 - Effects of heat stress on immunity of broilers in an experimental model of avian necrotic enteritis, BP.DR; + associated scholarships 13/13736-5 - Effects of Lactobacillus salivarius on immunity and intestinal commensal microbiota of heat-stressed broiler chickens infected with Salmonella Enteritidis, BP.PD; 12/22718-8 - Evaluation of Immune response parameters, intestinal morphometry and immunohistochemistry from broiler chicks under cold stress conditions and inoculated with two genetically diverse by virulence Salmonella Heidelberg clones., BP.PD; 12/07007-8 - Possible prevention or treatment of impairments induced by an early prenatal exposure to lipopolysaccharide in an experimental model of autism, BP.PD; 12/03372-3 - The influence of cohabitation with a sick cage mate on pulmonary allergic inflammatory response, BP.DR; 12/03103-2 - Evaluation of heat stress on the development of necrotic enteritis due to Clostridium perfringens in broilers, BP.MS; 11/16261-2 - Differentiation, endocytic capacity and antigen-presenting function of dendritic cells isolated from mice subjected to subdiaphragmatic vagotomy, BP.MS; 11/21856-5 - The role of neuroimunne regulation in the onset and progression of experimental inflamatory bowel disease, BP.DR; 11/10181-7 - "EFFECTS OF 2-AG, THROUGH MONOACYLGLYCEROL LIPASE INHIBITION, IN A MURINE MODEL OF ACUTE LUNG INJURY LPS-INDUCED", BP.DR; 11/03884-1 - Evaluation of participation parasympathetic nervous system in a model of food allergic response in mice, BP.MS; 11/01763-2 - Neuroimmunomodulation and the second brain: unraveling the interactions of the enteric nervous system with the immune system and the consequences of this crosstalk, BE.PQ; 10/11896-7 - DETECTION OF GFAP E VIMENTIN IN ENCEPHALITIS INDUCED BY INFECTION WITH EQUINE HERPESVIRUS TYPE 1 IN MICE'S BRAINS., BP.IC - associated scholarships

Abstract

The notion that cytokines play a relevant role as mediators among immune, endocrine and nervous system as well as the bidirectional nature of these relationships are now well established. The discovery of common receptors for cytokines and neurotransmitters on nervous and immune cells and the presence of neurotransmitters on lymphoid organs support the existence of these relationships. Cytokines were linked to behavioral alterations such as: disturbances in sleep, appetite, mood, cognition, motivation, energy and fatigue levels, sex drive, and depression and, for sure, to cancer and cardiovascular diseases. In the last 10 years, we have analyzed the relationships among stress /anxiety, innate immune activity and susceptibility to disease; we have also focused on the effects over the immune system of drugs that act on central nervous system (CNS). Some behavioral changes induced by immune reactions were also object of our research. Within this field, 60 scientific papers were published by our group in the last 10 years, 32 in the last 04 years. This thematic project aims on following up the ongoing research developed in our labs and supported by FAPESP (Projects n° 99/04228-7 and n° 04/14128-0). We particularly intent to evaluate, by means of 49 individual projects (object of undergraduate graduate studies and post-doctoral work) the effects of stress, neurotransmitters, CNS acting drugs and peripheral and pineal melatonin on parameters of inflammatory and immune responses; studies on behavioral changes induced by immune reactions, cytokines or LPS are also within our objectives. (AU)

Scientific publications

(45)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CALEFI, ATILIO SERSUN; QUINTEIRO-FILHO, WANDERLEY MORENO; DE SIQUEIRA, ADRIANA; NASCIMENTO LIMA, ANA PAULA; GIMENES CRUZ, DANIEL SANZIO; HAZARBASSANOV, NICOLLE QUEIROZ; SALVAGNI, FERNANDO AUCIELLO; BORSOI, ANDERLISE; MASSOCO SALLES GOMES, CRISTINA DE OLIVEIRA; MAIORKA, PAULO CESAR; PIANTINO FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Heat stress, Eimeria spp. and C. perfringens infections alone or in combination modify gut Th1/Th2 cytokine balance and avian necrotic enteritis pathogenesis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 210, p. 28-37, APR 2019. Web of Science Citations: 0.

CALEFI, ATILIO SERSUN; DE QUEIROZ NUNES, CATARINA AUGUSTA; DA SILVA FONSECA, JULIANA GARCIA; QUINTEIRO-FILHO, WANDERLEY MORENO; PIANTINO FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Heat stress reduces Eimeria spp. infection and interferes with C. perfringens infection via activation of the hypothalamic-pituitary-adrenal axis. Research in Veterinary Science, v. 123, p. 273-280, APR 2019. Web of Science Citations: 0.

BARRETO, TALITA ROSSETTO; COSTOLA-DE-SOUZA, CAROLINA; MARGATHO, RAFAEL OLIVEIRA; QUEIROZ-HAZARBASSANOV, NICOLLE; RODRIGUES, SANDRA CAMPOS; FELICIO, LUCIANO FREITAS; PALERMO-NETO, JOAO; ZAGER, ADRIANO. Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice. International Immunopharmacology, v. 56, p. 43-50, MAR 2018. Web of Science Citations: 6.

ZAGER, ADRIANO; BRANDAO, WESLEY NOGUEIRA; MARGATHO, RAFAEL OLIVEIRA; GIMENES CRUZ, DANIEL SANZIO; PERON, JEAN PIERRE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY; MORESCO, MONICA; PIZZA, FABIO; PLAZZI, GIUSEPPE; KORNUM, BIRGITTE RAHBEK; PALERMO-NETO, JOAO. Increased interferon-mediated immunity following in vitro and in vivo Modafinil treatment on peripheral immune cells. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 81, p. 297-305, FEB 2 2018. Web of Science Citations: 2.

ZAGER, ADRIANO; BRANDAO, WESLEY NOGUEIRA; MARGATHO, RAFAEL OLIVEIRA; PERON, JEAN PIERRE; TUFIK, SERGIO; ANDERSEN, MONICA LEVY; KORNUM, BIRGITTE RAHBEK; PALERMO-NETO, JOAO. The wake-promoting drug Modafinil prevents motor impairment in sickness behavior induced by LPS in mice: Role for dopaminergic D1 receptor. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 81, p. 468-476, FEB 2 2018. Web of Science Citations: 7.

NASCIMENTO, AMANDA FIORENTINA; KIRYCHUK, SHELLEY; BERNARDI, MARIA MARTHA; FELICIO, LUCIANO F. Zinc Alleviates Lipopolysaccharide Interference with Both Body Temperature and Sickness Behavior in Virgin Female Rats. NEUROIMMUNOMODULATION, v. 25, n. 2, p. 89-95, 2018. Web of Science Citations: 0.

OCHOA-AMAYA, JULIETA E.; QUEIROZ-HAZARBASSANOV, NICOLLE; NAMAZU, LILIAN B.; CALEFI, ATILIO S.; TOBARUELA, CARLA N.; MARGATHO, RAFAEL; PALERMO-NETO, JOAO; LIGEIRO DE OLIVEIRA, ANA P.; FELICIO, LUCIANO F. Short-Term Hyperprolactinemia Reduces the Expression of Purinergic P2X7 Receptors during Allergic Inflammatory Response of the Lungs. NEUROIMMUNOMODULATION, v. 25, n. 1, p. 34-41, 2018. Web of Science Citations: 0.

CALEFI, A. S.; QUINTEIRO-FILHO, W. M.; FERREIRA, A. J. P.; PALERMO-NETO, J. Neuroimmunomodulation and heat stress in poultry. WORLDS POULTRY SCIENCE JOURNAL, v. 73, n. 3, p. 493-504, SEP 2017. Web of Science Citations: 3.

MACHADO, THALITA R. M.; ALVES, GLAUCIE J.; QUINTEIRO-FILHO, WANDERLEY M.; PALERMO-NETO, JOAO. Cohabitation with an Ehrlich tumor-bearing cagemate induces immune but not behavioral changes in male mice. Physiology & Behavior, v. 169, p. 82-89, FEB 1 2017. Web of Science Citations: 1.

MARGATHO, RAFAEL O.; MASSOCO, CRISTINA DE O.; CALEFI, ATILIO S.; CRUZ, DANIEL S. G.; SANDINI, THAISA M.; ALVES, GLAUCIE JUSSILANE; FLORIO, JORGE C.; PALERMO-NETO, JOAO. Beta-Adrenergic Blockade Decreases the Neuroimmune Changes in Mice Induced by Cohabitation with an Ehrlich Tumor-Bearing Cage Mate. NEUROIMMUNOMODULATION, v. 24, n. 1, p. 40-53, 2017. Web of Science Citations: 0.

CALEFI, ATILIO SERSUN; DA SILVA FONSECA, JULIANA GARCIA; HAMADA COHN, DANIEL WAGNER; BUENO HONDA, BRUNO TAKASHI; COSTOLA-DE-SOUZA, CAROLINA; TSUGIYAMA, LUCILA EMIKO; QUINTEIRO-FILHO, WANDERLEY MORENO; PIANTINO FERREIRA, ANTONIO J.; PALERMO-NETO, JOAO. The gut-brain axis interactions during heat stress and avian necrotic enteritis. POULTRY SCIENCE, v. 95, n. 5, p. 1005-1014, MAY 2016. Web of Science Citations: 7.

OCHOA-AMAYA, JULIETA E.; MARINO, LARISSA P.; TOBARUELA, CARLA N.; NAMAZU, LILIAN B.; CALEFI, ATILIO S.; MARGATHO, RAFAEL; GONCALVES, JR., VAGNER; QUEIROZ-HAZARBASSANOV, NICOLLE; KLEIN, MARIANNE O.; PALERMO-NETO, JOAO; LIGEIRO DE OLIVEIRA, ANA P.; MASSOCO, CRISTINA DE O.; FELICIO, LUCIANO F. Attenuated allergic inflammatory response in the lungs during lactation. Life Sciences, v. 151, p. 281-287, APR 15 2016. Web of Science Citations: 2.

REIS-SILVA, THIAGO M.; COHN, DANIEL W. H.; SANDINI, THAISA M.; UDO, MARIANA S. B.; TEODOROV, ELIZABETH; BERNARDI, MARIA MARTHA. Prenatal lipopolysaccharide exposure affects sexual dimorphism in different germlines of mice with a depressive phenotype. Life Sciences, v. 149, p. 129-137, MAR 15 2016. Web of Science Citations: 1.

AS CALEFI; WM QUINTEIRO-FILHO; AR FUKUSHIMA; DSG DA CRUZ; A DE SIQUEIRA; FA SALVAGNI; LB NAMAZU; COMS GOMES; AJP FERREIRA; J PALERMO NETO. Dexamethasone Regulates Macrophage and Cd4+Cd25+ Cell Numbers in the Chicken Spleen. Brazilian Journal of Poultry Science, v. 18, n. 1, p. 93-100, Mar. 2016.

CALEFI, ATILIO SERSUN; DE SIQUEIRA, ADRIANA; NAMAZU, LILIAN BERNADETE; COSTOLA-DE-SOUZA, CAROLINA; TAKASHI HONDA, BRUNO BUENO; PIANTINO FERREIRA, ANTONIO JOSE; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; PALERMO-NETO, JOAO. Effects of heat stress on the formation of splenic germinal centres and immunoglobulins in broilers infected by Clostridium perfringens type A. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 171, p. 38-46, MAR 2016. Web of Science Citations: 8.

CALEFI, A. S.; QUINTEIRO-FILHO, W. M.; FUKUSHIMA, A. R.; DA CRUZ, D. S. G.; DE SIQUEIRA, A.; SALVAGNI, F. A.; NAMAZU, L. B.; GOMES, C. O. M. S.; FERREIRA, A. J. P.; PALERMO NETO, J. Dexamethasone Regulates Macrophage and Cd4+Cd25+Cell Numbers in the Chicken Spleen. Brazilian Journal of Poultry Science, v. 18, n. 1, p. 93-99, JAN-MAR 2016. Web of Science Citations: 4.

OCHOA-AMAYA, JULIETA E.; HAMASATO, EDUARDO K.; TOBARUELA, CARLA N.; QUEIROZ-HAZARBASSANOV, NICOLLE; ANSELMO FRANCI, JANETE A.; PALERMO-NETO, JOAO; GREIFFO, FLAVIA R.; DE BRITTO, AURILEIA APARECIDA; VIEIRA, RODOLFO PAULA; LIGEIRO DE OLIVEIRA, ANA P.; MASSOCO, CRISTINA DE O.; FELICIO, LUCIANO F. Short-term hyperprolactinemia decreases allergic inflammatory response of the lungs. Life Sciences, v. 142, p. 66-75, DEC 1 2015. Web of Science Citations: 7.

BUENO HONDA, BRUNO TAKASHI; CALEFI, ATILIO SERSUN; COSTOLA-DE-SOUZA, CAROLINA; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; DE PAULA, VIVIANE FERRAZ; PALERMO-NETO, JOAO. Effects of heat stress on peripheral T and B lymphocyte profiles and IgG and IgM serum levels in broiler chickens vaccinated for Newcastle disease virus. POULTRY SCIENCE, v. 94, n. 10, p. 2375-2381, OCT 2015. Web of Science Citations: 13.

KIRSTEN, THIAGO BERTI; CHAVES-KIRSTEN, GABRIELA P.; BERNARDES, SUENE; SCAVONE, CRISTOFORO; SARKIS, JORGE E.; BERNARDI, MARIA MARTHA; FELICIO, LUCIANO F. Lipopolysaccharide Exposure Induces Maternal Hypozincemia, and Prenatal Zinc Treatment Prevents Autistic-Like Behaviors and Disturbances in the Striatal Dopaminergic and mTOR Systems of Offspring. PLoS One, v. 10, n. 7 JUL 28 2015. Web of Science Citations: 16.

KIRSTEN, THIAGO B.; QUEIROZ-HAZARBASSANOV, NICOLLE; BERNARDI, MARIA M.; FELICIO, LUCIANO F. Prenatal zinc prevents communication impairments and BDNF disturbance in a rat model of autism induced by prenatal lipopolysaccharide exposure. Life Sciences, v. 130, p. 12-17, JUN 1 2015. Web of Science Citations: 20.

KIRSTEN, THIAGO B.; GALVAO, MARCELLA C.; REIS-SILVA, THIAGO M.; QUEIROZ-HAZARBASSANOV, NICOLLE; BERNARDI, MARIA M. Zinc Prevents Sickness Behavior Induced by Lipopolysaccharides after a Stress Challenge in Rats. PLoS One, v. 10, n. 3 MAR 16 2015. Web of Science Citations: 9.

RIBEIRO, A.; ALMEIDA, V. I.; COSTOLA-DE-SOUZA, C.; FERRAZ-DE-PAULA, V.; PINHEIRO, M. L.; VITORETTI, L. B.; GIMENES-JUNIOR, J. A.; AKAMINE, A. T.; CRIPPA, J. A.; TAVARES-DE-LIMA, W.; PALERMO-NETO, J. Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Immunopharmacology and Immunotoxicology, v. 37, n. 1, p. 35-41, FEB 2015. Web of Science Citations: 17.

ZAGER, ADRIANO; PERON, JEAN PIERRE; MENNECIER, GREGORY; RODRIGUES, SANDRA C.; ALOIA, THIAGO P.; PALERMO-NETO, JOAO. Maternal immune activation in late gestation increases neuroinflammation and aggravates experimental autoimmune encephalomyelitis in the offspring. BRAIN BEHAVIOR AND IMMUNITY, v. 43, p. 159-171, JAN 2015. Web of Science Citations: 19.

ALVES, GLAUCIE JUSSILANE; PALERMO-NETO, JOAO. Odor Cues Released by Ehrlich Tumor-Bearing Mice Are Aversive and Induce Psychological Stress. NEUROIMMUNOMODULATION, v. 22, n. 3, p. 121-129, 2015. Web of Science Citations: 2.

NASCIMENTO, AMANDA F.; ALVES, GLAUCIE JUSSILANE; MASSOCO, CRISTINA O.; TEODOROV, ELIZABETH; FELICIO, LUCIANO F.; BERNARDI, MARIA MARTHA. Lipopolysaccharide-Induced Sickness Behavior in Lactating Rats Decreases Ultrasonic Vocalizations and Exacerbates Immune System Activity in Male Offspring. NEUROIMMUNOMODULATION, v. 22, n. 4, p. 213-221, 2015. Web of Science Citations: 3.

FERRAZ-DE-PAULA, V.; RIBEIRO, A.; SOUZA-QUEIROZ, J.; PINHEIRO, M. L.; VECINA, J. F.; SOUZA, D. P. M.; QUINTEIRO-FILHO, W. M.; MOREAU, R. L. M.; QUEIROZ, M. L. S.; PALERMO-NETO, J. 3,4-Methylenedioxymethamphetamine (MDMA - Ecstasy) Decreases Neutrophil Activity Through the Glucocorticoid Pathway and Impairs Host Resistance to Listeria Monocytogenes Infection in Mice. JOURNAL OF NEUROIMMUNE PHARMACOLOGY, v. 9, n. 5, p. 690-702, DEC 2014. Web of Science Citations: 6.

HAMASATO, EDUARDO KENJI; NASCIMENTO DE LIMA, ANA PAULA; LIGEIRO DE OLIVEIRA, ANA PAULA; DOS SANTOS FRANCO, ADRIANA LINO; DE LIMA, WOTHAN TAVARES; PALERMO-NETO, JOAO. Cohabitation with a sick partner increase's allergic lung inflammatory response in mice. BRAIN BEHAVIOR AND IMMUNITY, v. 42, p. 109-117, NOV 2014. Web of Science Citations: 4.

PENTEADO, SANDRA H. W.; TEODOROV, ELIZABETH; KIRSTEN, THIAGO B.; ELUF, BIANCA P.; REIS-SILVA, THIAGO M.; ACENJO, MICHELLI K.; DE MELO, RAFAEL C.; SUFFREDINI, IVANA B.; BERNARDI, MARIA M. Prenatal lipopolysaccharide disrupts maternal behavior, reduces nest odor preference in pups, and induces anxiety: Studies of F1 and F2 generations. European Journal of Pharmacology, v. 738, p. 342-351, SEP 5 2014. Web of Science Citations: 7.

MARIA M. BERNARDI; LÍVIA P. TEIXEIRA; ANA P. LIGEIRO-DE-OLIVEIRA; WOTHAN TAVARES-DE-LIMA; JOÃO PALERMO-NETO; THIAGO B. KIRSTEN. Neonatal lipopolysaccharide exposure induces sexually dimorphic sickness behavior in adult rats. Psychology & Neuroscience, v. 7, n. 2, p. -, Jun. 2014.

CALEFI, ATILIO SERSUN; BUENO HONDA, BRUNO TAKASHI; COSTOLA-DE-SOUZA, CAROLINA; DE SIQUEIRA, ADRIANA; NAMAZU, LILIAN BERNADETE; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; ARRAIS ALOIA, THIAGO PINHEIRO; PIANTINO-FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Effects of long-term heat stress in an experimental model of avian necrotic enteritis. POULTRY SCIENCE, v. 93, n. 6, p. 1344-1353, JUN 2014. Web of Science Citations: 12.

GOMES, A. V. S.; QUINTEIRO-FILHO, W. M.; RIBEIRO, A.; FERRAZ-DE-PAULA, V.; PINHEIRO, M. L.; BASKEVILLE, E.; AKAMINE, A. T.; ASTOLFI-FERREIRA, C. S.; FERREIRA, A. J. P.; PALERMO-NETO, J. Overcrowding stress decreases macrophage activity and increases Salmonella Enteritidis invasion in broiler chickens. AVIAN PATHOLOGY, v. 43, n. 1, p. 82-90, JAN 2 2014. Web of Science Citations: 31.

PALERMO-NETO, JOAO; ALVES, GLAUCIE JUSSILANE. Neuroimmune Interactions and Psychologycal Stress Induced by Cohabitation with a Sick Partner: A Review. CURRENT PHARMACEUTICAL DESIGN, v. 20, n. 29, p. 4629-4641, 2014. Web of Science Citations: 6.

ZAGER, ADRIANO; ANDERSEN, MONICA L.; TUFIK, SERGIO; PALERMO-NETO, JOAO. Maternal Immune Activation Increases the Corticosterone Response to Acute Stress without Affecting the Hypothalamic Monoamine Content and Sleep Patterns in Male Mice Offspring. NEUROIMMUNOMODULATION, v. 21, n. 1, p. 37-44, 2014. Web of Science Citations: 4.

KIRSTEN, THIAGO B.; LIPPI, LUCIANA L.; BEVILACQUA, ESTELA; BERNARDI, MARIA M. LPS Exposure Increases Maternal Corticosterone Levels, Causes Placental Injury and Increases IL-1B Levels in Adult Rat Offspring: Relevance to Autism. PLoS One, v. 8, n. 12 DEC 2 2013. Web of Science Citations: 40.

ZAGER, ADRIANO; PINHEIRO, MILENA LOBAO; FERRAZ-DE-PAULA, VIVIANE; RIBEIRO, ALISON; PALERMO-NETO, JOAO. Increased cell-mediated immunity in male mice offspring exposed to maternal immune activation during late gestation. International Immunopharmacology, v. 17, n. 3, SI, p. 633-637, NOV 2013. Web of Science Citations: 5.

COSTOLA-DE-SOUZA, CAROLINA; RIBEIRO, ALISON; FERRAZ-DE-PAULA, VIVIANE; CALEFI, ATILIO SERSUN; ARRAIS ALOIA, THIAGO PINHEIRO; GIMENES-JUNIOR, JOAO ANTONIO; DE ALMEIDA, VINICIUS IZIDIO; PINHEIRO, MILENA LOBAO; PALERMO-NETO, JOAO. Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice. PLoS One, v. 8, n. 10 OCT 25 2013. Web of Science Citations: 28.

LINO-DOS-SANTOS-FRANCO, ADRIANA; GIMENES-JUNIOR, JOAO ANTONIO; LIGEIRO-DE-OLIVEIRA, ANA PAULA; BREITHAUPT-FALOPPA, ANA CRISTINA; ACCETURI, BEATRIZ GOLEGA; VITORETTI, LUANA BEATRIZ; MACHADO, ISABEL DAUFENBACK; OLIVEIRA-FILHO, RICARDO MARTINS; POLISELLI FARSKY, SANDRA HELENA; MORIYA, HENRIQUE TAKACHI; TAVARES-DE-LIMA, WOTHAN. Formaldehyde inhalation reduces respiratory mechanics in a rat model with allergic lung inflammation by altering the nitric oxide/cyclooxygenase-derived products relationship. Food and Chemical Toxicology, v. 59, p. 731-738, SEP 2013. Web of Science Citations: 4.

ROTH CARVALHO-FREITAS, MARIA ISABEL; ANSELMO-FRANCI, JANETE A.; PALERMO-NETO, JOAO; FELICIO, LUCIANO F. Prior reproductive experience alters prolactin-induced macrophage responses in pregnant rats. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 99, n. 1-2, p. 54-61, SEP 2013. Web of Science Citations: 6.

HAMASATO, EDUARDO KENJI; LIGEIRO DE OLIVEIRA, ANA PAULA; LINO-DOS-SANTOS-FRANCO, ADRIANA; RIBEIRO, ALISON; DE PAULA, VIVIANE FERRAZ; SCHATZMANN PERON, JEAN PIERRE; DAMAZO, AMILCAR SABINO; TAVARES-DE-LIMA, WOTHAN; PALERMO-NETO, JOAO. Effects of MK-801 and amphetamine treatments on allergic lung inflammatory response in mice. International Immunopharmacology, v. 16, n. 4, p. 436-443, AUG 2013. Web of Science Citations: 9.

LIGEIRO DE OLIVEIRA, ANA PAULA; SCHATZMANN PERON, JEAN PIERRE; SANTOS FRANCO, ADRIANA LINO; GOLEGA, BEATRIZ ACCETURI; VIEIRA, RODOLFO PAULA; MARTINEZ IBANEZ, OLGA CELIA; RIBEIRO, ORLANDO GARCIA; KOURY CABRERA, WAFA HANNA; DE FRANCO, MARCELO; OLIVEIRA-FILHO, RICARDO MARTINS; RIZZO, LUIZ VICENTE; VARGAFTIG, BERNARDO BORIS; DE LIMA, WOTHAN TAVARES. Ovariectomized OVA-Sensitized Mice Display Increased Frequency of CD4(+)Foxp3(+) T Regulatory Cells in the Periphery. PLoS One, v. 8, n. 6 JUN 17 2013. Web of Science Citations: 8.

GUERESCHI, MARCIA G.; ARAUJO, LEANDRO P.; MARICATO, JULIANA T.; TAKENAKA, MAISA C.; NASCIMENTO, VANESSA M.; VIVANCO, BRUNO C.; REIS, VANESSA O.; KELLER, ALEXANDRE C.; BRUM, PATRICIA C.; BASSO, ALEXANDRE S. Beta2-adrenergic receptor signaling in CD4(+) Foxp3(+) regulatory T cells enhances their suppressive function in a PKA-dependent manner. European Journal of Immunology, v. 43, n. 4, p. 1001-1012, APR 2013. Web of Science Citations: 53.

QUEIROZ, JULIA DE SOUZA; BARBOSA, CHRISTIANO M. V.; DA ROCHA, MICHELLE C.; BINCOLETTO, CLAUDIA; PAREDES-GAMERO, EDGAR J.; DE SOUZA QUEIROZ, MARY L.; PALERMO NETO, JOAO. Chlorella vulgaris treatment ameliorates the suppressive effects of single and repeated stressors on hematopoiesis. BRAIN BEHAVIOR AND IMMUNITY, v. 29, p. 39-50, MAR 2013. Web of Science Citations: 8.

LINO-DOS-SANTOS-FRANCO, ADRIANA; AMEMIYA, RENATA MIDORI; LIGEIRO DE OLIVEIRA, ANA PAULA; DAMAZO, AMILCAR SABINO; BREITHAUPT-FALOPPA, ANA CRISTINA; VITORETTI, LUANA BEATRIZ; ACCETURI, BEATRIZ GOLEGA; TAVARES-DE-LIMA, WOTHAN. The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin. Clinics, v. 68, n. 12, p. 1528-1536, 2013. Web of Science Citations: 3.

NASCIMENTO, AMANDA; BERNARDI, MARIA; PECORARI, VANESSA; MASSOCO, CHRISTINA; FELICIO, LUCIANO. Temporal Analysis of Lipopolysaccharide-Induced Sickness Behavior in Virgin and Lactating Female Rats. NEUROIMMUNOMODULATION, v. 20, n. 6, p. 305-312, 2013. Web of Science Citations: 5.

LIGEIRO DE OLIVEIRA, ANA PAULA; LINO-DOS-SANTOS-FRANCO, ADRIANA; ACCETURI, BEATRIZ GOLEGA; HAMASATO, EDUARDO KENJI; MACHADO, ISABEL DAUFENBACK; GIMENES JUNIOR, JOAO ANTONIO; VIEIRA, RODOLFO DE PAULA; DAMAZO, AMILCAR SABINO; POLISELLI FARSKY, SANDRA HELENA; TAVARES-DE-LIMA, WOTHAN; PALERMO-NETO, JOAO. Long-term amphetamine treatment exacerbates inflammatory lung reaction while decreases airway hyper-responsiveness after allergic stimulus in rats. International Immunopharmacology, v. 14, n. 4, p. 523-529, DEC 2012. Web of Science Citations: 7.