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The role of neuroimunne regulation in the onset and progression of experimental inflamatory bowel disease

Grant number: 11/21856-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): August 31, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Frederico Azevedo da Costa Pinto
Grantee:Ilana Gabanyi
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships, AP.TEM
Associated scholarship(s):12/11165-8 - Study of the neuroimmune interaction present in the intestine through enteric neurons and immune cells co-culture, BE.EP.DR


The inflammatory bowel disease (IBD) is a chronic and relapsing disease; its etiology hasn't been well established yet. Its origin involves a complex interaction between genetic and environmental factors, where the immune response to the intestinal microbiota plays an important role. Among the most relevant environmental factors are the cigar and the stress. Due to its role in monitoring the biggest area of the body exposed to the environment, the intestinal immune system receives a large variety of immunogenic stimulus. The intestinal immunity must be finely regulated, keeping the balance among a tolerance response and a response against pathogens. The unbalance between the regulation of cells and molecules pro and anti-inflammatory may cause the IBD. Besides the contact with the environment, the intestine also has the larger concentration of lymphocytes and antibodies of the body and the higher number of neurons, outside the central nervous system, which compose the enteric nervous system (ENS). The ENS also receives afferences from the sympathetic and parasympathetic autonomic nervous system (ANS) which participate actively in the maintenance of the intestinal epithelium integrity. The ANS may be implicated in the onset and progression of IBD, as the sympathetic ANS is associated with responsiveness to stress and the parasympathetic ANS is involved with the anti-inflamatory reflex. The interaction between the ANS and the IBD will be analysed using agonists and antagonists specific for ²2 adrenergic receptors and ±7 nicotinic receptors, in a murine model of IBD, during the chronic and acute phase, aiming a better understanding of the role of these pathways on the etiology of this disease.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GABANYI, Ilana. Identification of a cross-talk between neurons and macrophages in the intestine via β2 adrenergic receptors. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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