Effects of heat stress on immunity of broilers in an experimental model of avian necrotic enteritis

• Grant number: 13/17408-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): December 01, 2013
• Effective date (End): March 19, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: João Palermo Neto
• Grantee: Atilio Sersun Calefi
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships, AP.TEM

Abstract

Chicken meat has emerged in recent years for their protein quality and affordability. The poultry sector has the highest growth in production volume among all other meat sectors in Brazil. Therefore, the poultry industry has gained increasing importance in applied research. Thinking about the risk to public health, recently the European Union (EU) banned the use of prophylactic antimicrobial additives in animal feed. With this and coupled with intensive farming system in poultry, diseases hitherto controlled became reemerging, avian necrotic enteritis (NE) being a major reemerging diseases in the farms of the EU and of great concern in Brazil. NE is a disease that affects poultry production from 2 to 6 weeks old; primary etiological agent is Clostridium perfringens, a gram positive toxigenic and spore-forming anaerobic growth bacteria. It is estimated that the global loss due to subclinical necrotic enteritis exceed US$ 2 billion. Studies show that stress has an important role in the development of NE, but little is known about how it modulates such development. Considering the importance of the poultry industry in Brazil, studies focusing on the neuroimmune relations in broilers subjected to heat stress are important for understanding the pathogenic mechanisms of diseases such as NE. This project aims to assess the immune response and histopathological changes in an experimental model of necrotic enteritis with or without combination of coccidiosis in broilers subjected to heat stress and to correlate the findings through a neuroimmune approach. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AS CALEFI; WM QUINTEIRO-FILHO; AR FUKUSHIMA; DSG DA CRUZ; A DE SIQUEIRA; FA SALVAGNI; LB NAMAZU; COMS GOMES; AJP FERREIRA; J PALERMO NETO. Dexamethasone Regulates Macrophage and Cd4+Cd25+ Cell Numbers in the Chicken Spleen. Brazilian Journal of Poultry Science, v. 18, n. 1, p. 93-100, 2016-03-00. (12/03103-2, 09/51886-3, 13/17408-2)

CALEFI, A. S.; QUINTEIRO-FILHO, W. M.; FERREIRA, A. J. P.; PALERMO-NETO, J.. Neuroimmunomodulation and heat stress in poultry. WORLDS POULTRY SCIENCE JOURNAL, v. 73, n. 3, p. 493-504, SEP 2017. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DA SILVA FONSECA, JULIANA GARCIA; HAMADA COHN, DANIEL WAGNER; BUENO HONDA, BRUNO TAKASHI; COSTOLA-DE-SOUZA, CAROLINA; TSUGIYAMA, LUCILA EMIKO; QUINTEIRO-FILHO, WANDERLEY MORENO; PIANTINO FERREIRA, ANTONIO J.; PALERMO-NETO, JOAO. The gut-brain axis interactions during heat stress and avian necrotic enteritis. POULTRY SCIENCE, v. 95, n. 5, p. 1005-1014, MAY 2016. (12/03103-2, 13/17408-2, 09/51886-3)

BUENO HONDA, BRUNO TAKASHI; CALEFI, ATILIO SERSUN; COSTOLA-DE-SOUZA, CAROLINA; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; DE PAULA, VIVIANE FERRAZ; PALERMO-NETO, JOAO. Effects of heat stress on peripheral T and B lymphocyte profiles and IgG and IgM serum levels in broiler chickens vaccinated for Newcastle disease virus. POULTRY SCIENCE, v. 94, n. 10, p. 2375-2381, OCT 2015. (13/17408-2, 13/13736-5, 09/51886-3)

CALEFI, ATILIO SERSUN; DE SIQUEIRA, ADRIANA; NAMAZU, LILIAN BERNADETE; COSTOLA-DE-SOUZA, CAROLINA; TAKASHI HONDA, BRUNO BUENO; PIANTINO FERREIRA, ANTONIO JOSE; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; PALERMO-NETO, JOAO. Effects of heat stress on the formation of splenic germinal centres and immunoglobulins in broilers infected by Clostridium perfringens type A. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 171, p. 38-46, MAR 2016. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, A. S.; QUINTEIRO-FILHO, W. M.; FUKUSHIMA, A. R.; DA CRUZ, D. S. G.; DE SIQUEIRA, A.; SALVAGNI, F. A.; NAMAZU, L. B.; GOMES, C. O. M. S.; FERREIRA, A. J. P.; PALERMO NETO, J.. Dexamethasone Regulates Macrophage and Cd4+Cd25+Cell Numbers in the Chicken Spleen. Brazilian Journal of Poultry Science, v. 18, n. 1, p. 93-99, JAN-MAR 2016. (13/17408-2, 12/03103-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DE QUEIROZ NUNES, CATARINA AUGUSTA; DA SILVA FONSECA, JULIANA GARCIA; QUINTEIRO-FILHO, WANDERLEY MORENO; PIANTINO FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Heat stress reduces Eimeria spp. infection and interferes with C. perfringens infection via activation of the hypothalamic-pituitary-adrenal axis. Research in Veterinary Science, v. 123, p. 273-280, APR 2019. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; QUINTEIRO-FILHO, WANDERLEY MORENO; DE SIQUEIRA, ADRIANA; NASCIMENTO LIMA, ANA PAULA; GIMENES CRUZ, DANIEL SANZIO; HAZARBASSANOV, NICOLLE QUEIROZ; SALVAGNI, FERNANDO AUCIELLO; BORSOI, ANDERLISE; MASSOCO SALLES GOMES, CRISTINA DE OLIVEIRA; MAIORKA, PAULO CESAR; et al. Heat stress, Eimeria spp. and C. perfringens infections alone or in combination modify gut Th1/Th2 cytokine balance and avian necrotic enteritis pathogenesis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 210, p. 28-37, APR 2019. (12/03103-2, 13/17408-2, 09/51886-3)

CALEFI, ATILIO SERSUN; DA SILVA FONSECA, JULIANA GARCIA; DE QUEIROZ NUNES, CATARINA AUGUSTA; NASCIMENTO LIMA, ANA PAULA; QUINTEIRO-FILHO, WANDERLEY MORENO; FLORIO, JORGE CAMILO; ZAGER, ADRIANO; PIANTINO FERREIRA, ANTONIO JOSE; PALERMO-NETO, JOAO. Heat Stress Modulates Brain Monoamines and Their Metabolites Production in Broiler Chickens Co-Infected with Clostridium perfringens Type A and Eimeria spp.. VETERINARY SCIENCES, v. 6, n. 1, p. 14-pg., 2019-03-01. (09/51886-3, 13/17408-2, 12/03103-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CALEFI, Atilio Sersun. Effects of heat stress on immunity of broilers in experimental models of avian necrotic enteritis. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.