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Effects of Lactobacillus salivarius on immunity and intestinal commensal microbiota of heat-stressed broiler chickens infected with Salmonella Enteritidis

Grant number: 13/13736-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2013
Effective date (End): August 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:João Palermo Neto
Grantee:Wanderley Moreno Quinteiro Filho
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships, AP.TEM
Associated scholarship(s):15/00987-5 - Effects of Lactobacillus spp. on cytokine, avian defensins e toll-like receptors gene expression of heat-stressed broiler chickens infected with Salmonella Typhimurium, BE.EP.PD

Abstract

Stress is a reality in the world poultry production. Environmental stressors impair both welfare, performance parameters and immunity in broiler chickens. Heat stress decreases macrophage activity in broiler chickens and many environmental stressors that impact animal production increases animal's susceptibility to diseases. The neuroimmunomodulation is defined as the interrelationships between the Central Nervous System and the Immune System. Moreover, stressful events have been associated with disruption of intestinal commensal microbiota. We observed that the heat stress decreased performance parameters, relative weight of lymphoid organs, the macrophage activity and increased corticosterone serum levels. Furthermore, mild acute multifocal lymphoplasmacytic enteritis, characterized by foci of heterophil infiltration in the duodenum, jejunum and ileum, was observed in the heat stressed chickens. When chickens were experimetly infected with Salmonella Enteritidis, we observed an increase in Salmonella counts in the spleens of the stressed chickens. The probiotics have been used as an alternative to antimicrobial growth promoters for control food-borne pathogens (ie Salmonella). The Lactobacillus is one of the most important representatives of probiotics. There is increasing evidence that Lactobacillus is capable of modulating immune responses in humans and birds. In this way, the objective of the current study is to examine the effects of Lactobacillus salivarius on the immune system, intestinal morphology and commensal microbiota population in heat stressed broiler chickens experimentally infected with Salmonella Enteritidis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
QUINTEIRO-FILHO, W. M.; CALEFI, A. S.; CRUZ, D. S. G.; ALOIA, T. P. A.; ZAGER, A.; ASTOLFI-FERREIRA, C. S.; PIANTINO FERREIRA, J. A.; SHARIF, S.; PALERMO-NETO, J. Heat stress decreases expression of the cytokines, avian beta-defensins 4 and 6 and Toll-like receptor 2 in broiler chickens infected with Salmonella Enteritidis. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 186, p. 19-28, APR 2017. Web of Science Citations: 16.
QUINTEIRO-FILHO, W. M.; BRISBIN, J. T.; HODGINS, D. C.; SHARIF, S. Lactobacillus and Lactobacillus cell-free culture supernatants modulate chicken macrophage activities. Research in Veterinary Science, v. 103, p. 170-175, DEC 2015. Web of Science Citations: 3.
BUENO HONDA, BRUNO TAKASHI; CALEFI, ATILIO SERSUN; COSTOLA-DE-SOUZA, CAROLINA; QUINTEIRO-FILHO, WANDERLEY MORENO; DA SILVA FONSECA, JULIANA GARCIA; DE PAULA, VIVIANE FERRAZ; PALERMO-NETO, JOAO. Effects of heat stress on peripheral T and B lymphocyte profiles and IgG and IgM serum levels in broiler chickens vaccinated for Newcastle disease virus. POULTRY SCIENCE, v. 94, n. 10, p. 2375-2381, OCT 2015. Web of Science Citations: 13.

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