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The influence of cohabitation with a sick cage mate on pulmonary allergic inflammatory response

Grant number: 12/03372-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2012
Effective date (End): April 30, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:João Palermo Neto
Grantee:Eduardo Kenji Hamasato
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships, AP.TEM
Associated scholarship(s):13/25146-8 - Neural circuits activated during cohabitation with sick partner, BE.EP.DR


The bidirectional relationships between the nervous and immune systems are great importance for the maintenance of homeostasis. Our laboratory showed that the prolonged cohabitation with a sick cage mate (injected with cells of the tumor) caused changes in behavior and innate immunity and resistance decreases the growth of tumors. In particular, we report an increase in locomotor activity and turnover of norepinephrine in the hypothalamus and decreased the activity of macrophages and neutrophils, resistance decreases to a tumoral process. These facts led them to suggest that animals has markedly physiology and homeostasis changed by living with a sick cage mate, most likely triggered by olfactory stimulation from odors released by partner. This project will continue with these studies and intend to evaluate the influence of cohabitation for 14 days with sick cage mate (injected with tumor cells) on the development of allergic lung inflammation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HARNASATO, EDUARDO KENJI; LOVELOCK, DENNIS; PALERMO-NETO, JOAO; DEAK, TERRENCE. Assessment of social behavior directed toward sick partners and its relation to central cytokine expression in rats. Physiology & Behavior, v. 182, p. 128-136, . (13/25146-8, 12/03372-3)
HAMASATO, EDUARDO KENJI; NASCIMENTO DE LIMA, ANA PAULA; LIGEIRO DE OLIVEIRA, ANA PAULA; DOS SANTOS FRANCO, ADRIANA LINO; DE LIMA, WOTHAN TAVARES; PALERMO-NETO, JOAO. Cohabitation with a sick partner increase's allergic lung inflammatory response in mice. BRAIN BEHAVIOR AND IMMUNITY, v. 42, p. 109-117, . (12/03372-3, 09/51886-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
HAMASATO, Eduardo Kenji. The influence of cohabitation with sick partner on pulmonary allergic inflammatory response in mice. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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