| Texto completo | |
| Autor(es): |
Ayo, Christiane Maria
;
Frederico, Fabio Batista
;
Siqueira, Rubens Camargo
;
Brandao de Mattos, Cinara de Cassia
;
Previato, Mariana
;
Barbosa, Amanda Pires
;
Antunes Murata, Fernando Henrique
;
Silveira-Carvalho, Aparecida Perpetuo
;
de Mattos, Luiz Carlos
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 6, NOV 9 2016. |
| Citações Web of Science: | 4 |
| Resumo | |
The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with scars/lesions was further subdivided into two groups according to the type of ocular manifestation observed: primary (n = 120) or recurrent (n = 28). Genotyping was performed by PCR-SSOP. Statistical analyses were conducted using the Chi-square test, and odds ratio with a 95% confidence interval was also calculated to evaluate the risk association. The activating KIR3DS1 gene was associated with increased susceptibility for ocular toxoplasmosis. The activating KIR together with their HLA ligands (KIR3DS1-Bw4-80Ile and KIR2DS1(+)/C2(++) KIR3DS1(+)/Bw4-80Ile(+)) were associated with increased susceptibility for ocular toxoplasmosis and its clinical manifestations. KIR-HLA inhibitory pairs-KIR2DL3/2DL3-C1/C1 and KIR2DL3/2DL3-C1- were associated with decreased susceptibility for ocular toxoplasmosis and its clinical forms, while the KIR3DS1-/KIR3DL1(+)/Bw4-80Ile(+) combination was associated as a protective factor against the development of ocular toxoplasmosis and, in particular, against recurrent manifestations. Our data demonstrate that activating and inhibitory KIR genes may influence the development of ocular toxoplasmosis. (AU) | |
| Processo FAPESP: | 13/15879-8 - Infecção por Toxoplasma gondii: caracterização sorológica e molecular em pacientes atendidos pelo SUS |
| Beneficiário: | Fernando Henrique Antunes Murata |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 13/25650-8 - Genes HLA de classe II (DRB1 e DQB1) como fatores de risco para a toxoplasmose ocular |
| Beneficiário: | Luiz Carlos de Mattos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/06580-9 - Genes KIR, seus ligantes HLA e polimorfismo do gene MICA na toxoplasmose ocular e na forma digestiva da doença de Chagas |
| Beneficiário: | Christiane Maria Ayo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/10050-5 - Avaliação sorológica, molecular e de imagens em pacientes com lesão ativa e ou reagudização de infecção ocular por Toxoplasma gondii: um estudo de follow-up |
| Beneficiário: | Mariana Previato |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 09/17540-2 - Sistemas histo-sanguíneos como fatores de risco para a toxoplasmose ocular |
| Beneficiário: | Luiz Carlos de Mattos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |