| Full text | |
| Author(s): |
Ayo, Christiane Maria
;
Frederico, Fabio Batista
;
Siqueira, Rubens Camargo
;
Brandao de Mattos, Cinara de Cassia
;
Previato, Mariana
;
Barbosa, Amanda Pires
;
Antunes Murata, Fernando Henrique
;
Silveira-Carvalho, Aparecida Perpetuo
;
de Mattos, Luiz Carlos
Total Authors: 9
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 6, NOV 9 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with scars/lesions was further subdivided into two groups according to the type of ocular manifestation observed: primary (n = 120) or recurrent (n = 28). Genotyping was performed by PCR-SSOP. Statistical analyses were conducted using the Chi-square test, and odds ratio with a 95% confidence interval was also calculated to evaluate the risk association. The activating KIR3DS1 gene was associated with increased susceptibility for ocular toxoplasmosis. The activating KIR together with their HLA ligands (KIR3DS1-Bw4-80Ile and KIR2DS1(+)/C2(++) KIR3DS1(+)/Bw4-80Ile(+)) were associated with increased susceptibility for ocular toxoplasmosis and its clinical manifestations. KIR-HLA inhibitory pairs-KIR2DL3/2DL3-C1/C1 and KIR2DL3/2DL3-C1- were associated with decreased susceptibility for ocular toxoplasmosis and its clinical forms, while the KIR3DS1-/KIR3DL1(+)/Bw4-80Ile(+) combination was associated as a protective factor against the development of ocular toxoplasmosis and, in particular, against recurrent manifestations. Our data demonstrate that activating and inhibitory KIR genes may influence the development of ocular toxoplasmosis. (AU) | |
| FAPESP's process: | 13/15879-8 - Toxoplasma gondii infection: serological and molecular characterization in patients attended in public health service (SUS) |
| Grantee: | Fernando Henrique Antunes Murata |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 13/25650-8 - Class II HLA genes (DRB1 and DQB1) as risck factors for ocular toxoplasmosis |
| Grantee: | Luiz Carlos de Mattos |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/06580-9 - KIR genes, their HLA ligands and MICA gene polymorphism in ocular toxoplasmosis and in digestive form of Chagas disease |
| Grantee: | Christiane Maria Ayo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/10050-5 - Serological, molecular and images in patients with active lesions or acute relapse of ocular infection by Toxoplasma gondii: a study follow-up |
| Grantee: | Mariana Previato |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 09/17540-2 - Histo blood groups like risk factor for ocular toxoplasmosis |
| Grantee: | Luiz Carlos de Mattos |
| Support Opportunities: | Regular Research Grants |