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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

L-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?

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Autor(es):
Carta, Anna R. ; Mulas, Giovanna ; Bortolanza, Mariza ; Duarte, Terence ; Pillai, Elisabetta ; Fisone, Gilberto ; Vozari, Rita Raisman ; Del-Bel, Elaine
Número total de Autores: 8
Tipo de documento: Artigo de Revisão
Fonte: European Journal of Neuroscience; v. 45, n. 1, p. 73-91, JAN 2017.
Citações Web of Science: 0
Resumo

In Parkinson's disease (PD), L-DOPA therapy leads to the emergence of motor complications including L-DOPA-induced dyskinesia (LID). LID relies on a sequence of pre- and postsynaptic neuronal events, leading to abnormal corticostriatal neurotransmission and maladaptive changes in striatal projection neurons. In recent years, additional non-neuronal mechanisms have been proposed to contribute to LID. Among these mechanisms, considerable attention has been focused on L-DOPA-induced inflammatory responses. Microglia and astrocytes are the main actors in neuroinflammatory responses, and their double role at the interface between immune and neurophysiological responses is starting to be elucidated. Both microglia and astrocytes express a multitude of neurotransmitter receptors and via the release of several soluble molecules modulate synaptic function in neuronal networks. Here we review preclinical and clinical evidence of glial overactivation by L-DOPA, supporting a role of microglia and astrocytes in the development of LID. We propose that in PD, chronically and abnormally activated microglia and astrocytes lead to an aberrant neuron-glia communication, which affect synaptic activity and neuroplasticity contributing to the development of LID. (AU)

Processo FAPESP: 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos
Beneficiário:Francisco Silveira Guimaraes
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/25029-4 - Estudo da contribuição do processo inflamatório na discinesia induzida por L-DOPA na Doença de Parkinson
Beneficiário:Elaine Aparecida Del Bel Belluz Guimarães
Linha de fomento: Auxílio à Pesquisa - Temático