cipC is important for Aspergillus fumigatus virulence

Autor(es)

Spina Canela, Heliara Maria ; Takami, Luciano Akira ; da Silva Ferreira, Marcia Eliana

• Tipo de documento: Artigo Científico
• Fonte: APMIS; v. 125, n. 2, p. 141-147, FEB 2017.
• Citações Web of Science: 2

Resumo

Aspergillus fumigatus is the main causative agent of invasive aspergillosis, a disease that affects immunocompromised patients and has a high mortality rate. We previously observed that the transcription of a cipC-like gene was increased when A. fumigatus encountered an increased CO2 concentration, as occurs during the infection process. CipC is a protein of unknown function that might be associated with fungal pathogenicity. In this study, the cipC gene was disrupted in A. fumigatus to evaluate its importance for fungal pathogenicity. The gene was replaced, and the germination, growth phenotype, stress responses, and virulence of the resultant mutant were assessed. Although cipC was not essential, its deletion attenuated A. fumigatus virulence in a low-dose murine infection model, suggesting the involvement of the cipC gene in the virulence of this fungus. This study is the first to disrupt the cipC gene in A. fumigatus. (AU)

• Processo FAPESP: 08/06493-0 - Análise molecular da anidrase carbônica no fungo patogênico humano Aspergillus fumigatus
• Beneficiário: Márcia Eliana da Silva Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular