cipC is important for Aspergillus fumigatus virulence

Author(s)

Spina Canela, Heliara Maria ; Takami, Luciano Akira ; da Silva Ferreira, Marcia Eliana

• Document type: Journal article
• Source: APMIS; v. 125, n. 2, p. 141-147, FEB 2017.
• Web of Science Citations: 2

Abstract

Aspergillus fumigatus is the main causative agent of invasive aspergillosis, a disease that affects immunocompromised patients and has a high mortality rate. We previously observed that the transcription of a cipC-like gene was increased when A. fumigatus encountered an increased CO2 concentration, as occurs during the infection process. CipC is a protein of unknown function that might be associated with fungal pathogenicity. In this study, the cipC gene was disrupted in A. fumigatus to evaluate its importance for fungal pathogenicity. The gene was replaced, and the germination, growth phenotype, stress responses, and virulence of the resultant mutant were assessed. Although cipC was not essential, its deletion attenuated A. fumigatus virulence in a low-dose murine infection model, suggesting the involvement of the cipC gene in the virulence of this fungus. This study is the first to disrupt the cipC gene in A. fumigatus. (AU)

• FAPESP's process: 08/06493-0 - Molecular analysis of the carbonic anhydrase in the pathogenic fungus Aspergillus fumigatus
• Grantee: Márcia Eliana da Silva Ferreira
• Support type: Regular Research Grants