Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis

Autor(es)

Komegae, Evilin Naname ; Matozo Souza, Tais Aparecida ; Grund, Lidiane Zito ; Lima, Carla ; Lopes-Ferreira, Monica

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 12, n. 2 FEB 24 2017.
• Citações Web of Science: 2

Resumo

The pathological condition of multiple sclerosis (MS) relies on innate and adaptive immunity. New types of agents that beneficially modify the course of MS, stopping the progression and repairing the damage appear promising. Here, we studied TnP, a small stable synthetic peptide derived from fish venom in the control of inflammation and demyelination in experimental autoimmune encephalomyelitis as prophylactic treatment. TnP decreased the number of the perivascular infiltrates in spinal cord, and the activity of MMP-9 by F4/80+ macrophages were decreased after different regimen treatments. TnP reduces in the central nervous system the infiltration of IFN-gamma-producing Th1 and IL-17A-producing Th17 cells. Also, treatment with therapeutic TnP promotes the emergence of functional Treg in the central nervous system entirely dependent on IL-10. Therapeutic TnP treatment accelerates the remyelination process in a cuprizone model of demyelination. These findings support the beneficial effects of TnP and provides a new therapeutic opportunity for the treatment of MS. (AU)

• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 10/51130-3 - Efeito antiinflamatório das Natterinas e do peptídeo TNP, isolados do veneno de Thalassophryne nattereri, em um modelo de ancefalomielite autoimune experimental
• Beneficiário: Evilin Naname Komegae
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 03/13751-2 - Caracterização farmacológica, bioquímica e imunológica de venenos e toxinas de peixes peçonhentos do Brasil
• Beneficiário: Monica Valdyrce dos Anjos Lopes Ferreira
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
• Processo FAPESP: 12/50001-0 - Efeito antiflamatorio das Natterinas e do peptídeo tnp,isolado do veneno de Thalassophryne nattereri,em um modelo de encefalomielite autoimune experimental
• Beneficiário: Carla Lima da Silva
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 98/14307-9 - Center for Applied Toxinology
• Beneficiário: Hugo Aguirre Armelin
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs