| Full text | |
| Author(s): |
Komegae, Evilin Naname
;
Matozo Souza, Tais Aparecida
;
Grund, Lidiane Zito
;
Lima, Carla
;
Lopes-Ferreira, Monica
Total Authors: 5
|
| Document type: | Journal article |
| Source: | PLoS One; v. 12, n. 2 FEB 24 2017. |
| Web of Science Citations: | 4 |
| Abstract | |
The pathological condition of multiple sclerosis (MS) relies on innate and adaptive immunity. New types of agents that beneficially modify the course of MS, stopping the progression and repairing the damage appear promising. Here, we studied TnP, a small stable synthetic peptide derived from fish venom in the control of inflammation and demyelination in experimental autoimmune encephalomyelitis as prophylactic treatment. TnP decreased the number of the perivascular infiltrates in spinal cord, and the activity of MMP-9 by F4/80+ macrophages were decreased after different regimen treatments. TnP reduces in the central nervous system the infiltration of IFN-gamma-producing Th1 and IL-17A-producing Th17 cells. Also, treatment with therapeutic TnP promotes the emergence of functional Treg in the central nervous system entirely dependent on IL-10. Therapeutic TnP treatment accelerates the remyelination process in a cuprizone model of demyelination. These findings support the beneficial effects of TnP and provides a new therapeutic opportunity for the treatment of MS. (AU) | |
| FAPESP's process: | 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling |
| Grantee: | Hugo Aguirre Armelin |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 03/13751-2 - Caracterização farmacológica, bioquímica e imunológica de venenos e toxinas de peixes peçonhentos do Brasil |
| Grantee: | Monica Valdyrce dos Anjos Lopes Ferreira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 10/51130-3 - Efeito antiinflamatorio das natterinas e do peptideo tnp, isolados do veneno de thalassophryne nattereri, em um modelo de ancefalomielite autoimune experimental. |
| Grantee: | Evilin Naname Komegae |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 98/14307-9 - Center for Applied Toxinology |
| Grantee: | Hugo Aguirre Armelin |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 12/50001-0 - Efeito antiflamatorio das natterinas e do peptideo tnp,isolado do veneno de thalassophryne nattereri,em um modelo de encefalomielite autoimune experimental. |
| Grantee: | Carla Lima da Silva |
| Support Opportunities: | Regular Research Grants |