Molecular mechanisms of cardiac electromechanical remodeling during Chagas disease: Role of TNF and TGF-beta

Autor(es)

Cruz, Jader Santos ; Machado, Fabiana Simao ; Ropert, Catherine ; Roman-Campos, Danilo

• Tipo de documento: Artigo Científico
• Fonte: TRENDS IN CARDIOVASCULAR MEDICINE; v. 27, n. 2, p. 81-91, FEB 2017.
• Citações Web of Science: 6

Resumo

Chagas disease is caused by the trypanosomatid Trypanosoma cruzi, which chronically causes heart problems in up to 30% of infected patients. Chagas disease was initially restricted to Latin America. However, due to migratory events, this disease may become a serious worldwide health problem. During Chagas disease, many patients die of cardiac arrhythmia despite the apparent benefits of anti arrhythmic therapy (e.g., amiodarone). Here, we assimilate the cardiac form of Chagas disease to an inflammatory cardiac disease. Evidence from the literature, mostly provided using experimental models, supports this view and argues in favor of new strategies for treating cardiac arrhythmias in Chagas disease by modulating cytokine production and/or action. But the complex nature of myocardial inflammation underlies the need to better understand the molecular mechanisms of the inflammatory response during Chagas disease. Here, particular attention has been paid to tumor necrosis factor alpha (TNF) and transforming growth factor beta (TGF-beta) although other cytokines may be involved in the chagasic cardiomyopathy. (AU)

• Processo FAPESP: 14/09861-1 - Papel da corrente tardia de sódio nas arritmias cardíacas herdadas e adquiridas: da biofísica à procura de novos alvos terapêuticos
• Beneficiário: Danilo Roman Campos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores