Systems genetics and genome-wide association approaches for analysis of feed intake, feed efficiency, and performance in beef cattle

Autor(es)

Santana, M. H. A. ; Freua, M. C. ; Do, D. N. ; Ventura, R. V. ; Kadarmideen, H. N. ; Ferraz, J. B. S.

• Tipo de documento: Artigo Científico
• Fonte: Genetics and Molecular Research; v. 15, n. 4 2016.
• Citações Web of Science: 3

Resumo

Feed intake, feed efficiency, and weight gain are important economic traits of beef cattle in feedlots. In the present study, we investigated the physiological processes underlying such traits from the point of view of systems genetics. Firstly, using data from 1334 Nellore (Bos indicus) cattle and 943,577 single nucleotide polymorphisms (SNPs), a genome-wide association analysis was performed for dry matter intake, average daily weight gain, feed conversion ratio, and residual feed intake with a Bayesian Lasso procedure. Genes within 50-kb SNPs, most relevant for explaining the genomic variance, were annotated and the biological processes underlying the traits were inferred from Database for Annotation, Visualization and Integrated Discovery (DAVID) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Our results indicated several putative genomic regions associated with the target phenotypes and showed that almost all genomic variances were in the SNPs located in the intergenic and intronic regions. We further identified five main metabolic pathways related to ion transport, body composition, and feed intake control, which influenced the four phenotypes simultaneously. The systems genetics approach used in this study revealed novel pathways related to feed efficiency traits in beef cattle. (AU)

• Processo FAPESP: 13/20571-2 - Genômica funcional da ingestão e eficiência alimentar de bovinos da raça Nelore
• Beneficiário: Miguel Henrique de Almeida Santana
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/02039-9 - Estudo genômico da ingestão e eficiência alimentar em bovinos da raça Nelore
• Beneficiário: José Bento Sterman Ferraz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/14121-7 - Estudos de genética de sistemas de medidas de confinamento usando painel de SNP super-denso
• Beneficiário: Miguel Henrique de Almeida Santana
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 13/26902-0 - Uso da variância genética em modelos mecanicistas dinâmicos de crescimento para predizer o desempenho e a composição da carcaça de bovinos confinados
• Beneficiário: Mateus Castelani Freua
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/07566-2 - Genômica aplicada à produção de ruminantes
• Beneficiário: José Bento Sterman Ferraz
• Modalidade de apoio: Auxílio à Pesquisa - Temático