| Full text | |
| Author(s): |
Santana, M. H. A.
;
Freua, M. C.
;
Do, D. N.
;
Ventura, R. V.
;
Kadarmideen, H. N.
;
Ferraz, J. B. S.
Total Authors: 6
|
| Document type: | Journal article |
| Source: | Genetics and Molecular Research; v. 15, n. 4 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
Feed intake, feed efficiency, and weight gain are important economic traits of beef cattle in feedlots. In the present study, we investigated the physiological processes underlying such traits from the point of view of systems genetics. Firstly, using data from 1334 Nellore (Bos indicus) cattle and 943,577 single nucleotide polymorphisms (SNPs), a genome-wide association analysis was performed for dry matter intake, average daily weight gain, feed conversion ratio, and residual feed intake with a Bayesian Lasso procedure. Genes within 50-kb SNPs, most relevant for explaining the genomic variance, were annotated and the biological processes underlying the traits were inferred from Database for Annotation, Visualization and Integrated Discovery (DAVID) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Our results indicated several putative genomic regions associated with the target phenotypes and showed that almost all genomic variances were in the SNPs located in the intergenic and intronic regions. We further identified five main metabolic pathways related to ion transport, body composition, and feed intake control, which influenced the four phenotypes simultaneously. The systems genetics approach used in this study revealed novel pathways related to feed efficiency traits in beef cattle. (AU) | |
| FAPESP's process: | 14/07566-2 - Genomics applied to ruminant production |
| Grantee: | José Bento Sterman Ferraz |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/20571-2 - Functional genomics of feed intake and efficiency in Nellore cattle |
| Grantee: | Miguel Henrique de Almeida Santana |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 14/14121-7 - System genetics studies of feedlot traits using super-dense SNP panel |
| Grantee: | Miguel Henrique de Almeida Santana |
| Support type: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 13/26902-0 - Use of genetic variance in dynamic mechanistic models of growth to predict cattle performance and carcass composition under feedlot conditions |
| Grantee: | Mateus Castelani Freua |
| Support type: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/02039-9 - Genomic study of feed intake and efficiency in Nellore cattle |
| Grantee: | José Bento Sterman Ferraz |
| Support type: | Regular Research Grants |