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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systems genetics and genome-wide association approaches for analysis of feed intake, feed efficiency, and performance in beef cattle

Full text
Author(s):
Santana, M. H. A. ; Freua, M. C. ; Do, D. N. ; Ventura, R. V. ; Kadarmideen, H. N. ; Ferraz, J. B. S.
Total Authors: 6
Document type: Journal article
Source: Genetics and Molecular Research; v. 15, n. 4 2016.
Web of Science Citations: 3
Abstract

Feed intake, feed efficiency, and weight gain are important economic traits of beef cattle in feedlots. In the present study, we investigated the physiological processes underlying such traits from the point of view of systems genetics. Firstly, using data from 1334 Nellore (Bos indicus) cattle and 943,577 single nucleotide polymorphisms (SNPs), a genome-wide association analysis was performed for dry matter intake, average daily weight gain, feed conversion ratio, and residual feed intake with a Bayesian Lasso procedure. Genes within 50-kb SNPs, most relevant for explaining the genomic variance, were annotated and the biological processes underlying the traits were inferred from Database for Annotation, Visualization and Integrated Discovery (DAVID) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Our results indicated several putative genomic regions associated with the target phenotypes and showed that almost all genomic variances were in the SNPs located in the intergenic and intronic regions. We further identified five main metabolic pathways related to ion transport, body composition, and feed intake control, which influenced the four phenotypes simultaneously. The systems genetics approach used in this study revealed novel pathways related to feed efficiency traits in beef cattle. (AU)

FAPESP's process: 14/07566-2 - Genomics applied to ruminant production
Grantee:José Bento Sterman Ferraz
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/20571-2 - Functional genomics of feed intake and efficiency in Nellore cattle
Grantee:Miguel Henrique de Almeida Santana
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/14121-7 - System genetics studies of feedlot traits using super-dense SNP panel
Grantee:Miguel Henrique de Almeida Santana
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 13/26902-0 - Use of genetic variance in dynamic mechanistic models of growth to predict cattle performance and carcass composition under feedlot conditions
Grantee:Mateus Castelani Freua
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/02039-9 - Genomic study of feed intake and efficiency in Nellore cattle
Grantee:José Bento Sterman Ferraz
Support type: Regular Research Grants