Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats

Autor(es)

Duarte, Josiane O. ; Gomes, Karina S. ; Nunes-de-Souza, Ricardo L. ; Crestani, Carlos C.

• Tipo de documento: Artigo Científico
• Fonte: Physiology & Behavior; v. 175, p. 16-21, JUN 1 2017.
• Citações Web of Science: 4

Resumo

The lateral preoptic area (LPO) is connected with limbic structures involved in physiological and behavioral responses to stress. Accordingly, exposure to stressors stimuli activates neurons within the LPO. In spite of these evidence,. an involvement of the LPO on cardiovascular and neuroendocrine adjustments during aversive threats has not yet been investigated. Therefore, in the present study we tested the hypothesis that the LPO is involved in the control of cardiovascular and neuroendocrine responses to acute restraint stress in rats. Bilateral microinjection of the nonselective synaptic blocker CoCl2 (0.1 nmol/100 nl) into the LPO did not affect basal values of either arterial pressure, heart rate, tail skin temperature, or plasma corticosterone concentration. However, LPO treatment with CoCl2 enhanced the tachycardiac response and the increase in plasma corticosterone concentration caused by restraint stress. Conversely, LPO synaptic blockade decreased restraint-evoked pressor response. Sympathetic-mediated cutaneous vasoconstriction during restraint stress was not affected by LPO pharmacological treatment. These findings indicate an inhibitory influence of LPO on tachycardiac and plasma corticosterone responses evoked during aversive threats. Additionally, data suggest that LPO plays a facilitatory influence on stress-evoked pressor response. (AU)

• Processo FAPESP: 12/50549-6 - Envolvimento da neurotransmissão colinérgica no núcleo leito da estria terminal nas respostas autonômicas, neuroendócrinas e comportamentais desencadeadas pelo estresse por restrição agudo em ratos
• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/14376-0 - Comparação do efeito de dois protocolos de estresse crônico sobre a função cardiovascular e autonômica em ratos
• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/05922-9 - Estudo da participação da neurotransmissão CRFérgica do núcleo leito da estria terminal nas alterações cardiovasculares induzidas pelo estresse: interação com a via de sinalização receptor NMDA / óxido nítrico/guanilato ciclase / proteína quinase g?
• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/01888-2 - Estudo do efeito do estresse crônico sobre a função cardiovascular em ratos adolescentes e adultos
• Beneficiário: Josiane de Oliveira Duarte
• Modalidade de apoio: Bolsas no Brasil - Doutorado