| Texto completo | |
| Autor(es): |
Steluti, Josiane
;
Carvalho, Aline M.
;
Carioca, Antonio A. F.
;
Miranda, Andreia
;
Gattas, Gilka J. F.
;
Fisberg, Regina M.
;
Marchioni, Dirce M.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRIENTS; v. 9, n. 6 JUN 2017. |
| Citações Web of Science: | 2 |
| Resumo | |
Folate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of food fortification with folic acid showed a decrease of homocysteine concentration. The aim of this study was to investigate the frequencies of the polymorphisms of enzymes and carrier proteins involved in one-carbon metabolism, and to evaluate homocysteine concentrations in the presence of these genetic variants in a population exposed to mandatory food fortification with folic acid. Using data from a population-based cross-sectional study in Sao Paulo, Brazil, the study population comprised 750 participants above 12 years of age of both genders. A linear regression model was used to evaluate the homocysteine concentrations according to genetic variants and folate level. The results showed that the minor allelic frequencies were 0.33 for MTHFR (rs1801133), 0.24 for MTHFR (rs1801131), 0.19 for MTR (rs1805087), 0.42 for MTRR (rs1801394), 0.46 for RFC1 (rs1051266), and 0.47 for DHFR (19-bp deletion). The genetic variants of MTHFR 677C> T, MTRR 66A> G and RFC-1 80G> A were different according to race. The homocysteine concentrations increased in the CT and TT compared to CC genotypes of polymorphism MTHFR 677C> T in all populations, and differences between the homocysteine concentrations according to the genotypes of MTHFR 677C> T were observed regardless of folate level. (AU) | |
| Processo FAPESP: | 12/05505-0 - Padronização de metodologia e análise de ácido fólico não metabolizado após a fortificação mandatória com ácido fólico: estudo de base populacional no Município de São Paulo |
| Beneficiário: | Josiane Steluti |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 11/19788-1 - Avaliação da deficiência de folato após a fortificação mandatória de ácido fólico e consequências à saúde: estudo de base populacional no município de São Paulo |
| Beneficiário: | Dirce Maria Lobo Marchioni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 10/19899-5 - Consumo dietético, variantes genéticas e relação com os níveis sanguíneos de folato, ácido fólico não metabolizado e homocisteína após a fortificação mandatória de ácido fólico: estudo de base populacional - ISA-Capital. |
| Beneficiário: | Josiane Steluti |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |