Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

Autor(es)

N.C. Nogueira-de-Souza ^[1] ; I.D.C. Guerreiro da Silva ^[2] ; C.V. de Carvalho ^[3] ; A. Pulchinelli ^[4] ; M.A. Haidar ^[5] ; E.C. Baracat ^[6] ; A.M. Massad-Costa ^[7]

Afiliação do(s) autor(es)

^[1] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil

^[2] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil

^[3] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil

^[4] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil

^[5] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil

^[6] Universidade de São Paulo. Faculdade de Medicina. Departamento de Obstetrícia e Ginecologia - Brasil

^[7] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 42, n. 12, p. 1138-1142, 2009-12-00.

Resumo

Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT). A significant portion of the variability of these levels has been attributed to genetic factors. Therefore, we investigated the influence of estrogen receptor-alpha (ESR1) gene polymorphisms on HDL levels in response to postmenopausal HRT. We performed a prospective cohort study on 54 postmenopausal women who had not used HRT before the study and had no significant general medical illness. HRT consisted of conjugated equine estrogen and medroxyprogesterone acetate continuously for 1 year. The lipoprotein levels were measured from blood samples taken before the start of therapy and after 1 year of HRT. ESR1 polymorphism (MspI C>T, HaeIII C>T, PvuII C>T, and XbaI A>G) frequencies were assayed by restriction fragment length polymorphism. A general linear model was used to describe the relationships between HDL levels and genotypes after adjusting for age. A significant increase in HDL levels was observed after HRT (P = 0.029). Women with the ESR1 PvuII TT genotype showed a statistically significant increase in HDL levels after HRT (P = 0.032). No association was found between other ESR1 polymorphisms and HDL levels. According to our results, the ESR1 PvuII TT genotype was associated with increased levels of HDL after 1 year of HRT. (AU)

• Processo FAPESP: 03/04533-1 - Estudo de polimorfismo em genes responsáveis pela biossíntese, ação e metabolização de esteróides sexuais em afecções ginecológicas estrogênio-dependentes e no climatério
• Beneficiário: Ismael Dale Cotrim Guerreiro da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/05281-9 - Análise de polimorfismos nos genes CYP1A, CYP1B1, CYP3A4, CYP17, COLLIA1, COMT, GSTM1, osteocalcina, lipase hepática, receptor de vitamina D, receptor de estrogênios e progesterona em mulheres em terapia substitutiva com estrogênios e progestogênios
• Beneficiário: Ana Maria Massad Costa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado