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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

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Author(s):
N.C. Nogueira-de-Souza [1] ; I.D.C. Guerreiro da Silva [2] ; C.V. de Carvalho [3] ; A. Pulchinelli [4] ; M.A. Haidar [5] ; E.C. Baracat [6] ; A.M. Massad-Costa [7]
Total Authors: 7
Affiliation:
[1] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
[2] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
[3] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
[4] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
[5] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina. Departamento de Obstetrícia e Ginecologia - Brasil
[7] Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Ginecologia - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 42, n. 12, p. 1138-1142, 2009-12-00.
Abstract

Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT). A significant portion of the variability of these levels has been attributed to genetic factors. Therefore, we investigated the influence of estrogen receptor-alpha (ESR1) gene polymorphisms on HDL levels in response to postmenopausal HRT. We performed a prospective cohort study on 54 postmenopausal women who had not used HRT before the study and had no significant general medical illness. HRT consisted of conjugated equine estrogen and medroxyprogesterone acetate continuously for 1 year. The lipoprotein levels were measured from blood samples taken before the start of therapy and after 1 year of HRT. ESR1 polymorphism (MspI C>T, HaeIII C>T, PvuII C>T, and XbaI A>G) frequencies were assayed by restriction fragment length polymorphism. A general linear model was used to describe the relationships between HDL levels and genotypes after adjusting for age. A significant increase in HDL levels was observed after HRT (P = 0.029). Women with the ESR1 PvuII TT genotype showed a statistically significant increase in HDL levels after HRT (P = 0.032). No association was found between other ESR1 polymorphisms and HDL levels. According to our results, the ESR1 PvuII TT genotype was associated with increased levels of HDL after 1 year of HRT. (AU)

FAPESP's process: 03/04533-1 - Study of polymorphisms in genes responsible for biosynthesis, action and metabolization of sexual steroids in estrogen-dependent and menopausal gynecological conditions
Grantee:Ismael Dale Cotrim Guerreiro da Silva
Support Opportunities: Research Projects - Thematic Grants