Synthesis, characterization and antitumor activity of palladium(II) complexes of imidazolidine-2-thione

Autor(es)

de Moura, Thales R. ; Cavalcanti, Sahra L. ; de Godoy, Paulo R. D. V. ; Sakamoto-Hojo, Elza T. ; Rocha, Fillipe V. ; de Almeida, Eduardo T. ; Deflon, Victor M. ; Mauro, Antonio E. ; Netto, Adelino V. G.

• Tipo de documento: Artigo Científico
• Fonte: TRANSITION METAL CHEMISTRY; v. 42, n. 6, p. 565-574, SEP 2017.
• Citações Web of Science: 6

Resumo

Complexes of the type cis-{[}PdX2(imzt)(PPh3)] [imzt = imidazolidine-2-thione; PPh3 = triphenylphosphine; X = Cl (1), Br (2), I (3), SCN (4)] have been synthesized and characterized by elemental analyses, molar conductance, IR and H-1 NMR spectroscopies. The complex 1 center dot MeOH was obtained from the reaction of {[}PdCl2(CH3CN)(2)], imidazolidine-2-thione and triphenylphosphine in CHCl3/CH3OH. Complexes 2 center dot MeOH, 3 and 4 were prepared by metathesis of the chlorido ligands in 1 with bromide, iodide and thiocyanate, respectively. Elemental analyses showed good agreement with the expected mononuclear compositions, while the molar conductivities of the complexes in DMF were consistent with their nonelectrolytic nature. NMR spectra confirmed coordination of the imidazolidine-2-thione and triphenylphosphine ligands. Single-crystal X-ray diffraction determination of 1 center dot CH3OH showed that the coordination geometry around Pd-II is nearly square planar, with the chlorido ligands in a cis configuration. All four complexes have been tested in vitro by XTT assay for their cytotoxicity against human glioblastoma cell line (U87MG). The binding of 1 with guanosine was studied by H-1 NMR spectroscopy, revealing that the coordination takes place via N7. (AU)

• Processo FAPESP: 12/15486-3 - Compostos de Pd(II): síntese, citotoxicidade e investigação espectrofotométrica da interação com o DNA
• Beneficiário: Regina Celia Galvao Frem
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/17711-5 - Investigação do potencial antitumoral de compostos de paládio(ii) contendo ligantes ligantes ortometalados ou n,s-doadores
• Beneficiário: Adelino Vieira de Godoy Netto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/54011-8 - EMU: aquisição de difratômetro de raios X de monocristal para análise estrutural de moléculas pequenas e proteínas
• Beneficiário: Victor Marcelo Deflon
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários