Synthesis, characterization and antitumor activity of palladium(II) complexes of imidazolidine-2-thione

Author(s)

de Moura, Thales R. ; Cavalcanti, Sahra L. ; de Godoy, Paulo R. D. V. ; Sakamoto-Hojo, Elza T. ; Rocha, Fillipe V. ; de Almeida, Eduardo T. ; Deflon, Victor M. ; Mauro, Antonio E. ; Netto, Adelino V. G.

• Document type: Journal article
• Source: TRANSITION METAL CHEMISTRY; v. 42, n. 6, p. 565-574, SEP 2017.
• Web of Science Citations: 6

Abstract

Complexes of the type cis-{[}PdX2(imzt)(PPh3)] [imzt = imidazolidine-2-thione; PPh3 = triphenylphosphine; X = Cl (1), Br (2), I (3), SCN (4)] have been synthesized and characterized by elemental analyses, molar conductance, IR and H-1 NMR spectroscopies. The complex 1 center dot MeOH was obtained from the reaction of {[}PdCl2(CH3CN)(2)], imidazolidine-2-thione and triphenylphosphine in CHCl3/CH3OH. Complexes 2 center dot MeOH, 3 and 4 were prepared by metathesis of the chlorido ligands in 1 with bromide, iodide and thiocyanate, respectively. Elemental analyses showed good agreement with the expected mononuclear compositions, while the molar conductivities of the complexes in DMF were consistent with their nonelectrolytic nature. NMR spectra confirmed coordination of the imidazolidine-2-thione and triphenylphosphine ligands. Single-crystal X-ray diffraction determination of 1 center dot CH3OH showed that the coordination geometry around Pd-II is nearly square planar, with the chlorido ligands in a cis configuration. All four complexes have been tested in vitro by XTT assay for their cytotoxicity against human glioblastoma cell line (U87MG). The binding of 1 with guanosine was studied by H-1 NMR spectroscopy, revealing that the coordination takes place via N7. (AU)

• FAPESP's process: 12/15486-3 - Pd(II) compounds: synthesis, cytotoxicity, and DNA binding studies
• Grantee: Regina Celia Galvao Frem
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/17711-5 - INVESTIGATION OF THE ANTITUMOR POTENTIAL OF PALLADIUM(II) COMPOUNDS CONTAINING ORTHOMETALLATED OR N,S-DONOR LIGANDS
• Grantee: Adelino Vieira de Godoy Netto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/54011-8 - Acquisition of a single-crystal X-ray diffractometer for the structural analysis of small molecules and proteins
• Grantee: Victor Marcelo Deflon
• Support Opportunities: Multi-user Equipment Program