New strategies for targeting and treatment of multi-drug resistant Staphylococcus aureus

Autor(es)

Assis, L. Mayrink ; Nedeljkovic, M. ; Dessen, A.

• Tipo de documento: Artigo de Revisão
• Fonte: DRUG RESISTANCE UPDATES; v. 31, p. 1-14, MAR 2017.
• Citações Web of Science: 18

Resumo

Staphylococcus aureus is a major cause of bacterial infection in humans, and has been notoriously able to acquire resistance to a variety of antibiotics. An example is methicillin-resistant S. aureus (MRSA), which despite having been initially associated with clinical settings, now is one of the key causative agents of community-acquired infections. Antibiotic resistance in S. aureus involves mechanisms ranging from drug efflux to increased expression or mutation of target proteins, and this has required innovative approaches to develop novel treatment methodologies. This review provides an overview of the major mechanisms of antibiotic resistance developed by S. aureus, and describes the emerging alternatives being sought to circumvent infection and proliferation, including new generations of classic antibiotics, synergistic approaches, antibodies, and targeting of virulence factors. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/52067-6 - Estruturação de complexos macromoleculares da parede bacteriana: biossíntese e virulência
• Beneficiário: Andrea Dessen de Souza e Silva
• Linha de fomento: Auxílio à Pesquisa - Programa SPEC
• Processo FAPESP: 13/22681-0 - Caracterização estrutural de complexos membranários envolvidos na síntese da parede celular bacteriana
• Beneficiário: Lucas Mayrink Assis
• Linha de fomento: Bolsas no Brasil - Doutorado Direto