New strategies for targeting and treatment of multi-drug resistant Staphylococcus aureus

Author(s)

Assis, L. Mayrink ; Nedeljkovic, M. ; Dessen, A.

• Document type: Review article
• Source: DRUG RESISTANCE UPDATES; v. 31, p. 1-14, MAR 2017.
• Web of Science Citations: 18

Abstract

Staphylococcus aureus is a major cause of bacterial infection in humans, and has been notoriously able to acquire resistance to a variety of antibiotics. An example is methicillin-resistant S. aureus (MRSA), which despite having been initially associated with clinical settings, now is one of the key causative agents of community-acquired infections. Antibiotic resistance in S. aureus involves mechanisms ranging from drug efflux to increased expression or mutation of target proteins, and this has required innovative approaches to develop novel treatment methodologies. This review provides an overview of the major mechanisms of antibiotic resistance developed by S. aureus, and describes the emerging alternatives being sought to circumvent infection and proliferation, including new generations of classic antibiotics, synergistic approaches, antibodies, and targeting of virulence factors. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 13/22681-0 - Structural characterization of membrane protein complexes involved in bacterial cell wall biosynthesis
• Grantee: Lucas Mayrink Assis
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 11/52067-6 - Assembly and structure of macromolecular complexes involved in bacterial cell wall: biosynthesis and virulence
• Grantee: Andrea Dessen de Souza e Silva
• Support Opportunities: Research Projects - SPEC Program