High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice

Autor(es)

Carvalho, Adriana Lelis ^{[1, 2]} ; DeMambro, Victoria E. ^[2] ; Guntur, Anyonya R. ^[2] ; Le, Phuong ; Nagano, Kenichi ^[3] ; Baron, Roland ^[3] ; Albuquerque de Paula, Francisco Jose ^[1] ; Motyl, Katherine J. ^{[4, 5]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, Sao Paulo - Brazil

^[2] Maine Med Ctr, Res Inst, Ctr Clin & Translat Res, Scarborough, ME 04074 - USA

^[3] Harvard Univ, Harvard Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 - USA

^[4] Phuong Le, Maine Med Ctr, Res Inst, Ctr Clin & Translat Res, Scarborough, ME 04074 - USA

^[5] Maine Med Ctr, Res Inst, Ctr Mol Med, Scarborough, ME 04074 - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cellular Physiology; v. 233, n. 2, p. 1585-1600, FEB 2018.
• Citações Web of Science: 3

Resumo

There is a growing and alarming prevalence of obesity and the metabolic syndrome in type I diabetic patients (T1DM), particularly in adolescence. In general, low bone mass, higher fracture risk, and increased marrow adipose tissue (MAT) are features of diabetic osteopathy in insulin-deficient subjects. On the other hand, type 2 diabetes (T2DM) is associated with normal or high bone mass, a greater risk of peripheral fractures, and no change in MAT. Therefore, we sought to determine the effect of weight gain on bone turnover in insulin-deficient mice. We evaluated the impact of a 6-week high-fat (HFD) rich in medium chain fatty acids or low-fat diet (LFD) on bone mass and MAT in a streptozotocin (STZ)-induced model using male C57BL/6J mice at 8 weeks of age. Dietary intervention was initiated after diabetes confirmation. At the endpoint, lower non-fasting glucose levels were observed in diabetic mice fed with high fat diet compared to diabetic mice fed the low fat diet (STZ-LFD). Compared to euglycemic controls, the STZ-LFD had marked polydipsia and polyphagia, as well as reduced lean mass, fat mass, and bone parameters. Interestingly, STZ-HFD mice had higher bone mass, namely less cortical bone loss and more trabecular bone than STZ-LFD. Thus, we found that a HFD, rich in medium chain fatty acids, protects against bone loss in a T1DM mouse model. Whether this may also translate to T1DM patients who are overweight or obese in respect to maintenance of bone mass remains to be determined through longitudinal studies. (AU)

• Processo FAPESP: 14/14505-0 - Efeitos do balanço energético sobre a massa óssea e a adiposidade da medula óssea no diabetes melito do tipo 1
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/15864-3 - Relação da adiposidade visceral, hepática e óssea com a densidade mineral óssea e ocorrência de fratura no Diabetes melito tipo 1
• Beneficiário: Francisco José Albuquerque de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/09853-6 - Relação da Adiposidade Visceral, Hepática e Óssea com a Densidade Mineral Óssea e Ocorrência de Fratura no Diabetes Melito tipo 1.
• Beneficiário: Adriana Lelis Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado