Moxidectin residues in tissues of lambs submitted to three endoparasite control programs

Autor(es)

Machado Fernandes, Maria Angela ^[1] ; Gilaverte, Susana ^[1] ; Bianchi, Michele Dell ^[2] ; Araujo da Silva, Claudio Jose ^[1] ; Molento, Marcelo Beltrao ^[3] ; Reyes Reyes, Felix Guillermo ^[2] ; Gomes Monteiro, Alda Lucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Parana, Dept Anim Sci, Sheep & Goat Prod & Res Ctr LAPOC, Rua Funcionarios, 1540 Juveve, BR-80035050 Curitiba, Parana - Brazil

^[2] Univ Estadual Campinas, Dept Food Sci, Sch Food Engn, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP - Brazil

^[3] Univ Fed Parana, Lab Parasit Dis, Dept Vet Sci, Rua Funcionarios, 1540 Juveve, BR-80035050 Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Research in Veterinary Science; v. 114, p. 406-411, OCT 2017.
• Citações Web of Science: 4

Resumo

The indiscriminate and continuous use of anthelmintic drugs has promoted the selection of resistant parasites population, the presence of drug residues in food products, and heavy environmental contamination. The aim of the present study was to determine the presence of antiparasitic drug residues in 42-days old lamb serum and tissues, submitted to three endoparasite control programs: preventive treatment (PT) using moxidectin (MOX) at every 28 days; selective treatment (FEC) using MOX when fecal egg count was greater than or equal to 700; and selective treatment (FMC), using MOX when FAMACHA/FMC score was 3 and above. For this purpose, MOX residues were quantified in serum, muscle, fat, liver and kidney. Lambs were slaughtered when reaching 30 kg of body weight, and after a 28-day MOX withdrawal period. Before slaughter, blood was collected to determine the concentration of MOX in serum. Tissues and organ samples were collected at slaughter. The quantitation of MOX residues was performed using liquid chromatography tandem mass spectrometry (LC-MS/MS). From the 756 tissue samples analyzed, only one sample of fat from the PT group showed residue levels (586.3 mu g/kg) above the maximum residue limit (MRL) of 500 mu g/kg. No treated lambs presented traces of MOX residues in fat and liver, suggesting possible environmental contamination. In conclusion, all weaned lambs, produced in continuous grazing and subjected to gastrointestinal parasite control programs via selective (FEC and FMC) or preventive (PT) treatment, displayed a low risk (< 1%) of MOX residues above the MRL in muscle, fat, kidney, and liver. (AU)

• Processo FAPESP: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
• Beneficiário: Felix Guillermo Reyes Reyes
• Modalidade de apoio: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE