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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis

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Autor(es):
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Abreu, Patricia A. E. [1] ; Seguro, Antonio C. [2] ; Canale, Daniele [2] ; da Silva, Ana Maria G. [3] ; Matos, Larissa do R. B. [1] ; Gotti, Tatiane B. [1] ; Monaris, Denize [1] ; de Jesus, Denise A. [2] ; Vasconcellos, Silvio A. [4] ; de Brito, Thales [3] ; Magaldi, Antonio J. B. [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Butantan Inst, Lab Bacteriol, Sao Paulo - Brazil
[2] Clin Hosp, Lab Med Invest LIM12, Nephrol Dept, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Trop Med, Med Sch, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Vet Med & Anim Sci, Lab Bacterial Zoonosis, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PLoS Neglected Tropical Diseases; v. 11, n. 5 MAY 2017.
Citações Web of Science: 4
Resumo

Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality. (AU)

Processo FAPESP: 10/20525-2 - Avaliação do potencial imunogênico e vacinal das flagelinas de Leptospira interrogans sorovar Copenhageni
Beneficiário:Denize Monaris
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 06/54701-6 - Desenvolvimento de um vetor para expressão de lipoproteínas de Leptospira interrogans em Escherichia coli
Beneficiário:Patricia Antonia Estima Abreu de Aniz
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/17695-6 - Desenvolvimento de um teste dipstick para o diagnóstico da leptospirose animal
Beneficiário:Tatiana Barrionuevo Gotti
Linha de fomento: Bolsas no Brasil - Doutorado