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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis

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Author(s):
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Abreu, Patricia A. E. [1] ; Seguro, Antonio C. [2] ; Canale, Daniele [2] ; da Silva, Ana Maria G. [3] ; Matos, Larissa do R. B. [1] ; Gotti, Tatiane B. [1] ; Monaris, Denize [1] ; de Jesus, Denise A. [2] ; Vasconcellos, Silvio A. [4] ; de Brito, Thales [3] ; Magaldi, Antonio J. B. [2]
Total Authors: 11
Affiliation:
[1] Butantan Inst, Lab Bacteriol, Sao Paulo - Brazil
[2] Clin Hosp, Lab Med Invest LIM12, Nephrol Dept, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Trop Med, Med Sch, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Vet Med & Anim Sci, Lab Bacterial Zoonosis, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS Neglected Tropical Diseases; v. 11, n. 5 MAY 2017.
Web of Science Citations: 5
Abstract

Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality. (AU)

FAPESP's process: 10/20525-2 - Evaluation of immunogenic and vaccine potential of Leptospira interrogans sorovar Copenhageni flagellins.
Grantee:Denize Monaris
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/17695-6 - Development of a dipstick test for the diagnosis of animal leptospirosis
Grantee:Tatiana Barrionuevo Gotti
Support Opportunities: Scholarships in Brazil - Doctorate