Exercise attenuates dexamethasone-induced hypertension through an improvement of baroreflex activity independently of the renin-angiotensin system

Autor(es)

Constantino, Paula B. ^{[1, 2]} ; Dionisio, Thiago J. ^[3] ; Duchatsch, Francine ^{[1, 2]} ; Herrera, Naiara A. ^{[1, 2]} ; Duarte, Josiane O. ^{[1, 2]} ; Santos, Carlos F. ^[3] ; Crestani, Carlos C. ^{[1, 4]} ; Amaral, Sandra L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] UNESP, UFSCar, Joint Grad Program Physiol Sci, PIPGCF, Rodovia Washington Luiz, Km 235, Monjolinho 676, Sao Carlos, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Fac Sci, Dept Phys Educ, Ave Engn Luiz Edmundo Carrijo Coube 14-01, Bauru, SP - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil

^[4] Sao Paulo State Univ UNESP, Pharmacol Lab, Sch Pharmaceut Sci, Rodovia Araraquara Jau, Km 01 S-N, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Steroids; v. 128, p. 147-154, DEC 2017.
• Citações Web of Science: 1

Resumo

Dexamethasone-induced hypertension may be caused by baroreflex alterations or renin-angiotensin system (RAS) exacerbation. Aerobic training has been recommended for hypertension treatment, but the mechanisms responsible for reduction of arterial pressure (AP) in dexamethasone (DEX) treated rats are still inconclusive.This study evaluated whether mechanisms responsible for training -induced attenuation of hypertension involve changes in autonomic nervous system and in RAS components. Rats underwent aerobic training protocol on treadmill or were kept sedentary for 8 weeks. Additionally, animals were treated with DEX during the last 10 days of exercise. Body weight (BW), AP and baroreflex activity were analyzed. Tibialis anterior (TA), coleus (SOL) and left ventricle (LV) were collected for evaluation of RAS components gene expression and protein levels. Dexamethasone decreased BW (20%), caused TA atrophy (16%) and increased systolic AP (SAP, 16%) as well as decreased baroreflex activity. Training attenuated SAP increase and improved baroreflex activity, although it did not prevent DEX-induced BW reduction and muscle atrophy. Neither DEX nor training caused expressive changes in RAS components. In conclusion, exercise training was effective in attenuating hypertension induced by DEX and this response may be mediated by a better autonomic balance through an improvement of baroreflex activity rather than changes in RAS components. (AU)

• Processo FAPESP: 14/23050-6 - Efeitos do tratamento agudo e de curta duração com dexametasona: papel do sistema renina angiotensina e do sistema nervoso autônomo
• Beneficiário: Francine Duchatsch Ribeiro de Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/19722-3 - Efeitos do pré-condicionamento físico na hipertensão induzida pela dexametasona: papel do sistema renina angiotensina
• Beneficiário: Paula Bessi Constantino Prazeres
• Modalidade de apoio: Bolsas no Brasil - Mestrado
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• Beneficiário: Carlos Cesar Crestani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Beneficiário: Sandra Lia do Amaral Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Modalidade de apoio: Bolsas no Brasil - Mestrado