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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exercise attenuates dexamethasone-induced hypertension through an improvement of baroreflex activity independently of the renin-angiotensin system

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Author(s):
Constantino, Paula B. [1, 2] ; Dionisio, Thiago J. [3] ; Duchatsch, Francine [1, 2] ; Herrera, Naiara A. [1, 2] ; Duarte, Josiane O. [1, 2] ; Santos, Carlos F. [3] ; Crestani, Carlos C. [1, 4] ; Amaral, Sandra L. [1, 2]
Total Authors: 8
Affiliation:
[1] UNESP, UFSCar, Joint Grad Program Physiol Sci, PIPGCF, Rodovia Washington Luiz, Km 235, Monjolinho 676, Sao Carlos, SP - Brazil
[2] Sao Paulo State Univ UNESP, Fac Sci, Dept Phys Educ, Ave Engn Luiz Edmundo Carrijo Coube 14-01, Bauru, SP - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil
[4] Sao Paulo State Univ UNESP, Pharmacol Lab, Sch Pharmaceut Sci, Rodovia Araraquara Jau, Km 01 S-N, BR-14800903 Araraquara, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Steroids; v. 128, p. 147-154, DEC 2017.
Web of Science Citations: 1
Abstract

Dexamethasone-induced hypertension may be caused by baroreflex alterations or renin-angiotensin system (RAS) exacerbation. Aerobic training has been recommended for hypertension treatment, but the mechanisms responsible for reduction of arterial pressure (AP) in dexamethasone (DEX) treated rats are still inconclusive.This study evaluated whether mechanisms responsible for training -induced attenuation of hypertension involve changes in autonomic nervous system and in RAS components. Rats underwent aerobic training protocol on treadmill or were kept sedentary for 8 weeks. Additionally, animals were treated with DEX during the last 10 days of exercise. Body weight (BW), AP and baroreflex activity were analyzed. Tibialis anterior (TA), coleus (SOL) and left ventricle (LV) were collected for evaluation of RAS components gene expression and protein levels. Dexamethasone decreased BW (20%), caused TA atrophy (16%) and increased systolic AP (SAP, 16%) as well as decreased baroreflex activity. Training attenuated SAP increase and improved baroreflex activity, although it did not prevent DEX-induced BW reduction and muscle atrophy. Neither DEX nor training caused expressive changes in RAS components. In conclusion, exercise training was effective in attenuating hypertension induced by DEX and this response may be mediated by a better autonomic balance through an improvement of baroreflex activity rather than changes in RAS components. (AU)

FAPESP's process: 14/23050-6 - Effects of dexamethasone short-time treatment: role of renin-angiotensin-system and autonomic nervous system
Grantee:Francine Duchatsch Ribeiro de Souza
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/21522-0 - Role of renin-antiotensin-system and simpathetic nervous system in dexamethasone-induced hypertension: preventive effects of exercise training
Grantee:Sandra Lia do Amaral Cardoso
Support type: Regular Research Grants
FAPESP's process: 12/14376-0 - Comparison of the effect of two protocols of chronic stress in cardiovascular and autonomic functions in rats
Grantee:Carlos Cesar Crestani
Support type: Regular Research Grants
FAPESP's process: 14/18177-7 - Effects of physical exercise on hypertension and oxidative stress in dexamethasone-treated rats
Grantee:Naiara Araújo Herrera
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/19722-3 - Physical precinditioning effects on Dexamethasone-induced hypertensio: role of Renin-Angiotensin System
Grantee:Paula Bessi Constantino Prazeres
Support type: Scholarships in Brazil - Master