Upregulation of Ghrelin Gene Expression in the Excluded Stomach of Obese Women with Type 2 Diabetes After Roux-en-Y Gastric Bypass in the SURMetaGIT Study

Autor(es)

Fonseca, Danielle Cristina ^[1] ; Sala, Priscila ^[1] ; Singer, Joelle ^{[2, 3]} ; Singer, Pierre ^{[2, 3]} ; Torrinhas, Raquel Susana ^[1] ; Waitzberg, Dan Linetzky ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med FMUSP, Lab Metanutri LIM 35, Dept Gastroenterol, Sao Paulo, SP - Brazil

^[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv - Israel

^[3] Belinson Hosp, Rabin Med Ctr, Endocrine Inst, Jabotinski St, Petah Tiqwa - Israel

• Tipo de documento: Artigo Científico
• Fonte: OBESITY SURGERY; v. 28, n. 3, p. 877-880, MAR 2018.
• Citações Web of Science: 3

Resumo

Mechanisms of type 2 diabetes remission (T2Dr) after Roux-en-Y gastric bypass (RYGB) in obese patients appear to involve gastrointestinal hormones. The objective of this study is to explore changes in ghrelin plasma levels and ghrelin gastrointestinal gene expression (GHRL) after RYGB, and their relationships to T2Dr. In 20 obese women with T2D, before and 3 months after RYGB, we assessed GHRL expression by microarray and quantitative RT-PCR in gastrointestinal biopsy samples and plasma levels of ghrelin. After RYGB, GHRL expression increased in the excluded stomach (p < 0.05) with no change in other gastrointestinal sites. There were no significant changes in ghrelin plasma levels and no correlations with T2Dr. After RYGB, over-expression of GHRL gene occurs only in the excluded stomach with no correlation to T2Dr. (AU)

• Processo FAPESP: 13/03246-0 - Estudo genômico, proteômico e metabolômico do tecido gastrointestinal de portadores de Diabetes melito tipo 2 após gastroplastia redutora a Y-Roux
• Beneficiário: Priscila Sala Kobal
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 11/09612-3 - Alterações na expressão gênica do tecido gástrico e intestinal de portadores de Diabetes melito tipo 2 submetidos à gastroplastia redutora a Y-Roux
• Beneficiário: Dan Linetzky Waitzberg
• Modalidade de apoio: Auxílio à Pesquisa - Temático