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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Coffee Consumption and Coronary Artery Calcium Score: Cross-Sectional Results of ELSA-Brasil (Brazilian Longitudinal Study of Adult Health)

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Autor(es):
Miranda, Andreia M. [1] ; Steluti, Josiane [1] ; Goulart, Alessandra C. [2] ; Bensenor, Isabela M. [2] ; Lotufo, Paulo A. [2] ; Marchioni, Dirce M. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF THE AMERICAN HEART ASSOCIATION; v. 7, n. 7 APR 3 2018.
Citações Web of Science: 4
Resumo

BackgroundAvailable evidence for the relationship between coffee intake and subclinical atherosclerosis is limited and inconsistent. This study aimed to evaluate the association between coffee consumption and coronary artery calcium (CAC) in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). Methods and ResultsThis cross-sectional study is based on baseline data from participants of the ELSA-Brasil cohort. Only participants living in SAo Paulo, Brazil, who underwent a CAC measurement (n=4426) were included. Coffee consumption was collected using a food frequency questionnaire. CAC was detected with computed tomography and expressed as Agatston units. CAC was further categorized as an Agatson score 100 (CAC 100). In multiple logistic regression analysis considering intake of coffee and smoking status interaction, significant inverse associations were observed between coffee consumption (>3 cups/d) and CAC100 (odds ratio {[}OR]: 0.85 {[}95% confidence interval, 0.58-1.24] for 1 cup/d; OR: 0.73 {[}95% confidence interval, 0.51-1.05] for 1-3 cups/d; OR: 0.33 {[}95% confidence interval, 0.17-0.65] for >3 cups/d). Moreover, there was a statistically significant interaction effect for coffee consumption and smoking status (P=0.028 for interaction). After stratification by smoking status, the analysis revealed a lower OR of coronary calcification in never smokers drinking >3 cups/d (OR: 0.37 {[}95% confidence interval, 0.15-0.91]), whereas among current and former smokers, the intake of coffee was not significantly associated with coronary calcification. ConclusionsHabitual consumption of >3 cups/d of coffee decreased odds of subclinical atherosclerosis among never smokers. The consumption of coffee could exert a potential beneficial effect against coronary calcification, particularly in nonsmokers. (AU)

Processo FAPESP: 11/12256-4 - Escore de cálcio e anatomia coronariana na identificação de risco de doença coronariana no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
Beneficiário:Paulo Andrade Lotufo
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/04540-2 - Estudo epidemiológico do consumo do café, sua contribuição na ingestão de polifenóis e seus potenciais efeitos nos fatores de risco cardiovascular, considerando variações genéticas individuais
Beneficiário:Andreia Alexandra Machado Miranda
Linha de fomento: Bolsas no Brasil - Doutorado