First phylogenetic analysis of dengue virus serotype 4 circulating in Espirito Santo state, Brazil, in 2013 and 2014

Autor(es)

Vicente, C. R. ^{[1, 2]} ; Pannuti, C. S. ^[3] ; Urbano, P. R. ^[3] ; Felix, A. C. ^[3] ; Cerutti Junior, C. ^[2] ; Herbinger, K. -H. ^[4] ; Froeschl, G. ^[1] ; Romano, C. M. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Munich, Med Ctr, Ctr Int Hlth, Munich - Germany

^[2] Univ Fed Espirito Santo, Dept Social Med, Ave Marechal Campos 1468, BR-29040090 Vitoria - Brazil

^[3] Univ Sao Paulo, Inst Trop Med, Sao Paulo - Brazil

^[4] Univ Munich, Med Ctr, Div Infect Dis & Trop Med, Munich - Germany

• Tipo de documento: Artigo Científico
• Fonte: EPIDEMIOLOGY AND INFECTION; v. 146, n. 1, p. 100-106, JAN 2018.
• Citações Web of Science: 2

Resumo

The purpose of the present study was to reconstruct the phylogeny of dengue virus serotype 4 (DENV-4) that was circulating in Espirito Santo state, Brazil, in 2013 and 2014, and to discuss the epidemiological implications associated with this evolutionary hypothesis. Partial envelope gene of eight DENV-4 samples from Espirito Santo state were sequenced and aligned with 72 worldwide DENV-4 reference sequences from GenBank. A phylogenetic tree was reconstructed through Bayesian Inference and the Time of the Most Recent Common Ancestor was estimated. The study detected the circulation of DENV-4 genotype II in Espirito Santo state, which was closely related to strains from the states of Mato Grosso collected in 2012 and of Sao Paulo sampled in 2015. This cluster emerged around 2011, approximately 4 years after the entry of the genotype II in Brazil through its northern states, possibly imported from Venezuela and Colombia. This is so far the first phylogenetic study of the DENV-4 circulating in Espirito Santo state and shows the importance of an internal route of dengue viral circulation in Brazil to the introduction of the virus into this state. (AU)

• Processo FAPESP: 12/15381-7 - Caracterização de mutações adaptativas no vírus da dengue sorotipo 2 (DENV2) cultivados em diferentes sistemas, através de sequenciamento em larga escala
• Beneficiário: Camila Malta Romano
• Modalidade de apoio: Auxílio à Pesquisa - Regular