Capsaicin reduces genotoxicity, colonic cell proliferation and preneoplastic lesions induced by 1,2-dimethylhydrazine in rats

Autor(es)

Ramos Caetano, Brunno Felipe ^[1] ; Tablas, Mariana Baptista ^[2] ; Ferreira Pereira, Natalia Elias ^[2] ; de Moura, Nelci Antunes ^[2] ; Carvalho, Robson Francisco ^[2] ; Marchesan Rodrigues, Maria Aparecida ^[1] ; Barbisan, Luis Fernando ^[2]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Med Sch, Dept Pathol, BR-18618687 Botucatu, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, BR-18618689 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Toxicology and Applied Pharmacology; v. 338, p. 93-102, JAN 1 2018.
• Citações Web of Science: 3

Resumo

Capsaicin (8-Methyl-N-vanillyl-(trans)-6-nonenamide) is the major pungent ingredient found in chili peppers consumed worldwide. Most reports on capsaicin potential carcinogenicity have yielded inconsistent findings. Some studies have shown that capsaicin exerts anti-proliferative and pro-apoptotic effects on different cancer cell lines, while others have reported an association between capsaicin at high doses with mutagenicity and carcinogenicity. Thus, this study aimed at assessing the effects of capsaicin administration on 1,2-dimethyl-hydrazine (DMH)-induced colon carcinogenesis in male Wistar rats. Our results show that capsaicin administration, before and during carcinogen exposure, modified DMH-induced cytotoxicity and genotoxicity, promoting anti-proliferative and pro-apoptotic responses through the expression of the genes involved in apoptosis, cell cycle suppression and cell/tissue differentiation. Furthermore, capsaicin reduced aberrant crypt foci (ACF) number and multiplicity, although there were no differences in tumor incidence and multiplicity among the groups. Taken together, the results suggest that capsaicin may have a preventive effect against DMH-induced colorectal carcinogenesis. (AU)

• Processo FAPESP: 14/24762-0 - Quimioprevenção do câncer do cólon pela capsaicina: influência nas etapas de iniciação e promoção em modelo de carcinogênese do cólon pela dimetilhidrazina no rato
• Beneficiário: Maria Aparecida Marchesan Rodrigues Kobayasi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/21951-6 - Efeitos da capsaicina na etapa de iniciação da carcinogênese química de colón em ratos
• Beneficiário: Brunno Felipe Ramos Caetano
• Modalidade de apoio: Bolsas no Brasil - Mestrado