Leukocyte telomere length variation in different stages of schizophrenia

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Maurya, Pawan Kumar ^{[1, 2]} ; Rizzo, Lucas Bortolotto ^{[1, 3]} ; Xavier, Gabriela ^{[4, 1]} ; Tempaku, Priscila Farias ^{[5, 6]} ; Ota, Vanessa Kiyomi ^{[4, 1]} ; Santoro, Marcos L. ^{[4, 1]} ; Spindola, Leticia M. ^{[4, 1]} ; Moretti, Patricia S. ^{[4, 1]} ; Mazzotti, Diego R. ^[7] ; Gadelha, Ary ^{[1, 6]} ; Gouvea, Eduardo S. ^[8] ; Noto, Cristiano ^{[1, 6]} ; Maes, Michael ^{[9, 10]} ; Cordeiro, Quirino ^[8] ; Bressan, Rodrigo A. ^{[1, 6]} ; Brietzke, Elisa ^{[1, 3, 6]} ; Belangero, Sintia Iole ^{[4, 1]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[2] Amity Univ Uttar Pradesh, Amity Inst Biotechnol, Noida - India

^[3] Res Grp Behav & Mol Neurosci Bipolar Disorder, Silo Paulo - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Morphol & Genet, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo - Brazil

^[6] Program Recognit & Intervent Individuals At Risk, Sao Paulo - Brazil

^[7] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 - USA

^[8] Santa Casa Misericordia Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[9] Chulalongkorn Univ, Dept Psychiat, Bangkok - Thailand

^[10] Univ Estadual Londrina, Graduat Program Hlth Sci, Londrina, PR - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PSYCHIATRIC RESEARCH; v. 96, p. 218-223, JAN 2018.
• Citações Web of Science: 10

Resumo

Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naive FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity. Telomere length (TL) was determined using a multiplex qPCR assay. After adjustment for age, years of education, and smoking status, we found that patients with SCZ had longer TL (relative ratio (RR) = 1.08) than the HC group (RR = 1.00, Wald chi(2) = 12.48, p = 0.002). Further, non-remitted SCZ patients presented longer TL (RR = 1.00) compared to remitted SCZ (RR = 0.88, Wald chi(2) = 7.20, p = 0.007). TL in patients also correlated to psychopathology assessment in terms of total (p = 0.003) and positive PANSS scores (p = 0.001). No correlation with negative PANSS, YMRS, and CDSS or effects of medication was found on TL. Although the exact pathways underlying longer TL in SCZ patients remain unclear, these findings raise more questions than answers and suggest that TL may be of immense value on SCZ progression. Further studies are required to investigate the association of TL in FEP and SCZ. (AU)

• Processo FAPESP: 10/08968-6 - Investigação de marcadores genéticos e epigenéticos: uma abordagem translacional para o tratamento de esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/07280-1 - Busca por marcadores genéticos de risco, de progressão e de reposta ao tratamento na esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular