Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates

Autor(es):Mostrar menos -

Faria, Karina Morais ^[1] ; Prado Ribeiro, Ana Carolina ^[1] ; Brandao, Thais Bianca ^[1] ; Silva, Wagner Gomes ^{[1, 2]} ; Lopes, Marcio Ajudarte ^[2] ; Pereira, Juliana ^[3] ; Alves, Marcelo Correa ^[4] ; Gueiros, Luiz Alcino ^[5] ; Shintaku, Werner Harumiti ^[6] ; Migliorati, Cesar Augusto ^[6] ; Santos-Silva, Alan Roger ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Dent Oncol Serv, Av Dr Arnaldo 251, BR-01246000 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Hematol Serv, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Luiz Queiroz Coll Agr, Tech Sect Informat, Sao Paulo - Brazil

^[5] Univ Fed Pernambuco, Dept Clin & Prevent Dent, Recife, PE - Brazil

^[6] Univ Tennessee, Ctr Hlth Sci, Coll Dent, Dept Diagnost Sci & Oral Med, Memphis, TN 38163 - USA

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE AMERICAN DENTAL ASSOCIATION; v. 149, n. 5, p. 382-391, MAY 2018.
• Citações Web of Science: 1

Resumo

Background. The purpose of this study was to evaluate whether intravenous (IV) bisphosphonate (BP) therapy can change the radiographic patterns of multiple myeloma (MM) in the jawbones. Methods. The authors evaluated panoramic radiographs obtained from 188 patients with MM for the presence of solitary osteolytic lesions, multiple osteolytic lesions, diffuse osteoporosis, diffuse sclerosis, lamina dura abnormalities, nonhealing alveolar sockets, and bone sequestration. The authors compared results obtained from patients treated with IV BPs with those obtained from patients who had never been exposed to BPs. Results. Multiple osteolytic lesions (P = .001), diffuse osteoporosis (P = .001), and diffuse sclerosis (P = .0036) occurred more often in the mandible in both groups. Solitary osteolytic lesions occurred less frequently in the BP group (P = .0078). Lamina dura abnormalities (P = .0006) and nonhealing alveolar sockets (P = .0021) were associated with BP treatment. Conclusions. IV BP therapy changes the radiographic patterns of MM in the jawbones. Practical Implications. The effect of BPs in the maxillofacial area is a matter of concern for health practitioners because this type of medication causes several alterations of the jawbones in patients with cancer. (AU)

• Processo FAPESP: 12/06138-1 - Estudo prospectivo da incidência de trismo induzido por radioterapia em pacientes com carcinoma espinocelular de boca
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/00429-7 - 2013 Annual Meeting (of The American Academy of Oral Medicine (AAOM)
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior
• Processo FAPESP: 13/18402-8 - Avaliação dos efeitos diretos da radiação sobre o esmalte, a dentina e a polpa dental de pacientes com câncer de cabeça e pescoço
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular