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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Radiographic patterns of multiple myeloma in the jawbones of patients treated with intravenous bisphosphonates

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Faria, Karina Morais [1] ; Prado Ribeiro, Ana Carolina [1] ; Brandao, Thais Bianca [1] ; Silva, Wagner Gomes [1, 2] ; Lopes, Marcio Ajudarte [2] ; Pereira, Juliana [3] ; Alves, Marcelo Correa [4] ; Gueiros, Luiz Alcino [5] ; Shintaku, Werner Harumiti [6] ; Migliorati, Cesar Augusto [6] ; Santos-Silva, Alan Roger [2]
Total Authors: 11
[1] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Dent Oncol Serv, Av Dr Arnaldo 251, BR-01246000 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Inst Canc Estado Sao Paulo, Hematol Serv, Sao Paulo - Brazil
[4] Univ Sao Paulo, Luiz Queiroz Coll Agr, Tech Sect Informat, Sao Paulo - Brazil
[5] Univ Fed Pernambuco, Dept Clin & Prevent Dent, Recife, PE - Brazil
[6] Univ Tennessee, Ctr Hlth Sci, Coll Dent, Dept Diagnost Sci & Oral Med, Memphis, TN 38163 - USA
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF THE AMERICAN DENTAL ASSOCIATION; v. 149, n. 5, p. 382-391, MAY 2018.
Web of Science Citations: 1

Background. The purpose of this study was to evaluate whether intravenous (IV) bisphosphonate (BP) therapy can change the radiographic patterns of multiple myeloma (MM) in the jawbones. Methods. The authors evaluated panoramic radiographs obtained from 188 patients with MM for the presence of solitary osteolytic lesions, multiple osteolytic lesions, diffuse osteoporosis, diffuse sclerosis, lamina dura abnormalities, nonhealing alveolar sockets, and bone sequestration. The authors compared results obtained from patients treated with IV BPs with those obtained from patients who had never been exposed to BPs. Results. Multiple osteolytic lesions (P = .001), diffuse osteoporosis (P = .001), and diffuse sclerosis (P = .0036) occurred more often in the mandible in both groups. Solitary osteolytic lesions occurred less frequently in the BP group (P = .0078). Lamina dura abnormalities (P = .0006) and nonhealing alveolar sockets (P = .0021) were associated with BP treatment. Conclusions. IV BP therapy changes the radiographic patterns of MM in the jawbones. Practical Implications. The effect of BPs in the maxillofacial area is a matter of concern for health practitioners because this type of medication causes several alterations of the jawbones in patients with cancer. (AU)

FAPESP's process: 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma
Grantee:Ana Carolina Prado Ribeiro e Silva
Support type: Regular Research Grants
FAPESP's process: 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients
Grantee:Alan Roger dos Santos Silva
Support type: Regular Research Grants
FAPESP's process: 13/00429-7 - 2013 Annual Meeting (of The American Academy of Oral Medicine (AAOM)
Grantee:Alan Roger dos Santos Silva
Support type: Research Grants - Meeting - Abroad