Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Autor(es)

Piva, Roger Honorato ^[1] ; Rocha, Marina Campos ^[2] ; Piva, Diogenes Honorato ^[3] ; Klegues Montedo, Oscar Rubem ^[4] ; Imasato, Hidetake ^[1] ; Malavazi, Iran ^[2] ; Rodrigues-Filho, Ubirajara Pereira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Grp Quim Mat Hibridos & Inorgan, Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Ctr Ciencias Biol & Saude, Dept Genet & Evolucao, Sao Carlos, SP - Brazil

^[3] Univ Fed Sao Carlos, PPG CEM, Sao Carlos, SP - Brazil

^[4] Univ Extremo Sul Catarinense, Grp Pesquisa Ceram Tecn CERTEC, PPGCEM, Criciuma, SC - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS CHEMISTRY B; v. 6, n. 1, p. 143-152, JAN 7 2018.
• Citações Web of Science: 1

Resumo

The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs2.5H0.5PW12O40) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs2.5H0.5PW12O40 nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H3O+), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens. (AU)

• Processo FAPESP: 15/17541-0 - Estudo da relação da via da integridade da parede celular e de genes de resposta ao estresse térmico no fungo patogênico humano Aspergillus fumigatus
• Beneficiário: Iran Malavazi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/16098-8 - Superfícies antimicrobianas bioinspiradas no manto ácido humano utilizando heteropoliácidos tipo Keggin
• Beneficiário: Roger Honorato Piva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado