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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

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Author(s):
Piva, Roger Honorato [1] ; Rocha, Marina Campos [2] ; Piva, Diogenes Honorato [3] ; Klegues Montedo, Oscar Rubem [4] ; Imasato, Hidetake [1] ; Malavazi, Iran [2] ; Rodrigues-Filho, Ubirajara Pereira [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Grp Quim Mat Hibridos & Inorgan, Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Ctr Ciencias Biol & Saude, Dept Genet & Evolucao, Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, PPG CEM, Sao Carlos, SP - Brazil
[4] Univ Extremo Sul Catarinense, Grp Pesquisa Ceram Tecn CERTEC, PPGCEM, Criciuma, SC - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF MATERIALS CHEMISTRY B; v. 6, n. 1, p. 143-152, JAN 7 2018.
Web of Science Citations: 1
Abstract

The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs2.5H0.5PW12O40) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs2.5H0.5PW12O40 nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H3O+), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens. (AU)

FAPESP's process: 15/17541-0 - Study of the relationship between genes involved in the cell wall integrity maintenance and thermotolerance in the human pathogenic fungi Aspergillus fumigatus
Grantee:Iran Malavazi
Support Opportunities: Regular Research Grants
FAPESP's process: 16/16098-8 - Antimicrobial surfaces bionspired by the acid mantle based on Keggin-type heteropoly acids
Grantee:Roger Honorato Piva
Support Opportunities: Scholarships in Brazil - Post-Doctoral