| Texto completo | |
| Autor(es): |
Teixeira, Silvania da Silva
[1]
;
Panveloski-Costa, Ana C.
[1]
;
Carvalho, Aline
[1]
;
Monteiro Schiavon, Fabiana P.
[2]
;
Ruiz Marque, Any de Castro
[2]
;
Campello, Raquel S.
[1]
;
Bazotte, Roberto B.
[2]
;
Nunes, Maria T.
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil
[2] Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, Parana - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PHYSIOLOGICAL REPORTS; v. 4, n. 18 SEP 2016. |
| Citações Web of Science: | 7 |
| Resumo | |
The thyroid hormone (TH) plays an important role in glucose metabolism. Recently, we showed that the TH improves glycemia control by decreasing cytokines expression in the adipose tissue and skeletal muscle of alloxan-induced diabetic rats, which were also shown to present primary hypothyroidism. In this context, this study aims to investigate whether the chronic treatment of diabetic rats with T3 could affect other tissues that are involved in the control of glucose homeostasis, as the liver and kidney. Adult Male Wistar rats were divided into nondiabetic, diabetic, and diabetic treated with T3 (1.5 mu g/100 g BW for 4 weeks). Diabetes was induced by alloxan monohydrate (150 mg/kg, BW, i.p.). Animals showing fasting blood glucose levels greater than 250 mg/dL were selected for the study. After treatment, we measured the blood glucose, serum T3, T4, TSH, and insulin concentration, hepatic glucose production by liver perfusion, liver PEPCK, GAPDH, and pAKT expression, as well as urine glucose concentration and renal expression of SGLT2 and GLUT2. T3 reduced blood glucose, hepatic glucose production, liver PEPCK, GAPDH, and pAKT content and the renal expression of SGLT2 and increased glycosuria. Results suggest that the decreased hepatic glucose output and increased glucose excretion induced by T3 treatment are important mechanisms that contribute to reduce serum concentration of glucose, accounting for the improvement of glucose homeostasis control in diabetic rats. (AU) | |
| Processo FAPESP: | 10/18151-7 - Caracterização das ações dos HT e do seu agonista GC-1 na regulação da homeostase glicêmica: estudo em células musculares e em ratos diabéticos |
| Beneficiário: | Silvania da Silva Teixeira |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 11/09014-9 - Efeitos do hormônio tireoidiano na modulação da expressão de citocinas envolvidas na sinalização da insulina na vigência de obesidade ou diabetes |
| Beneficiário: | Ana Carolina Panveloski Costa Salomão |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 13/05629-4 - Ações genômicas vs não genômicas dos hormônios tiroidianos: mudanças de paradigmas, implicações fisiológicas e perspectivas terapêuticas |
| Beneficiário: | Maria Tereza Nunes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |