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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats

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Author(s):
Teixeira, Silvania da Silva [1] ; Panveloski-Costa, Ana C. [1] ; Carvalho, Aline [1] ; Monteiro Schiavon, Fabiana P. [2] ; Ruiz Marque, Any de Castro [2] ; Campello, Raquel S. [1] ; Bazotte, Roberto B. [2] ; Nunes, Maria T. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil
[2] Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PHYSIOLOGICAL REPORTS; v. 4, n. 18 SEP 2016.
Web of Science Citations: 7
Abstract

The thyroid hormone (TH) plays an important role in glucose metabolism. Recently, we showed that the TH improves glycemia control by decreasing cytokines expression in the adipose tissue and skeletal muscle of alloxan-induced diabetic rats, which were also shown to present primary hypothyroidism. In this context, this study aims to investigate whether the chronic treatment of diabetic rats with T3 could affect other tissues that are involved in the control of glucose homeostasis, as the liver and kidney. Adult Male Wistar rats were divided into nondiabetic, diabetic, and diabetic treated with T3 (1.5 mu g/100 g BW for 4 weeks). Diabetes was induced by alloxan monohydrate (150 mg/kg, BW, i.p.). Animals showing fasting blood glucose levels greater than 250 mg/dL were selected for the study. After treatment, we measured the blood glucose, serum T3, T4, TSH, and insulin concentration, hepatic glucose production by liver perfusion, liver PEPCK, GAPDH, and pAKT expression, as well as urine glucose concentration and renal expression of SGLT2 and GLUT2. T3 reduced blood glucose, hepatic glucose production, liver PEPCK, GAPDH, and pAKT content and the renal expression of SGLT2 and increased glycosuria. Results suggest that the decreased hepatic glucose output and increased glucose excretion induced by T3 treatment are important mechanisms that contribute to reduce serum concentration of glucose, accounting for the improvement of glucose homeostasis control in diabetic rats. (AU)

FAPESP's process: 10/18151-7 - Characterization of actions of TH and its agonist GC-1 in the homeostasis glycemic: study in muscle cells and diabetic rats
Grantee:Silvania da Silva Teixeira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/09014-9 - EFFECTS OF THYROID HORMONE IN MODULATING THE EXPRESSION OF CYTOKINES INVOLVED IN INSULIN SIGNALING DURING OBESITY OR DIABETES
Grantee:Ana Carolina Panveloski Costa Salomão
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/05629-4 - Genomic vs nongenomic actions of thyroid hormones: changes of paradigms, physiological implications and therapeutical perspectives
Grantee:Maria Tereza Nunes
Support Opportunities: Research Projects - Thematic Grants