Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3

Autor(es)

Chaves, Matheus Andrade ^[1] ; Oseliero Filho, Pedro Leonidas ^[2] ; Jange, Camila Garcia ^{[3, 1]} ; Sinigaglia-Coimbra, Rita ^[4] ; Pinto Oliveira, Cristiano Luis ^[2] ; Pinho, Samantha Cristina ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Food Engn, Sch Anim Sci & Food Engn, Av Duque Caxias Norte 225, Pirassununga, SP - Brazil

^[2] Univ Sao Paulo, Inst Phys, Rua Matao 1371, Sao Paulo, SP - Brazil

^[3] Purdue Univ, Dept Agr & Biol Engn, W Lafayette, IN 47907 - USA

^[4] Univ Fed Sao Paulo, Electron Microscopy Ctr, Rua Botucatu 862, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 549, p. 112-121, JUL 20 2018.
• Citações Web of Science: 6

Resumo

This study aimed the production of multilamellar liposomes coencapsulating two hydrophobic bioactives, curcumin and vitamin D-3, which present antioxidant and nutraceutical properties. Liposomes were produced by proliposomes hydration and stabilized with a mixture of xanthan and guar gums. Proliposomes were produced by coating of micronized sucrose method. Physicochemical properties of the dispersions were evaluated over 42 days of refrigerated storage. Microstructural characterization were performed by differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS) and small deformation rheological analyses. Liposomes showed spherical and near-spherical shapes and presented hydrodynamic diameters in the 680-1580 nm range. Curcumin and cholecalciferol were loaded into the same vesicles, with preservation efficiencies ranging from 89.6 to 93.3% and from 88.3 to 91.3%, respectively, after 42 days of storage. SAXS data showed that the lipid bilayer of liposomes produced in the presence of curcumin, vitamin D-3, or a mixture of both, are very similar. Also, higher amounts of vitamin D-3 did not affect negatively the stability of phospholipid vesicles. Overall, it was demonstrated that the coencapsulation of curcumin and vitamin D-3 by liposomes is feasible and high contents of bioactives were retained throughout the storage time. (AU)

• Processo FAPESP: 14/23376-9 - Estabilidade de lipossomas multilamelares encapsulando curcumina: avaliação de diferentes polissacarídeos como espessantes de dispersões produzidas por hidratação de pró-lipossomas
• Beneficiário: Camila Garcia Jange
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/03362-6 - Coencapsulação de curcumina e vitamina d3 em lipossomas multilamelares
• Beneficiário: Matheus Andrade Chaves
• Modalidade de apoio: Bolsas no Brasil - Mestrado