Triiodothyronine differentially modulates the LH and FSH synthesis and secretion in male rats

Autor(es)

Romano, Renata Marino ^[1] ; Bargi-Souza, Paula ^[1] ; Brunetto, Erika Lia ^[1] ; Goulart-Silva, Francemilson ^[1] ; Salgado, Renato M. ^[2] ; Tenorio Zorn, Telma Maria ^[2] ; Nunes, Maria Tereza ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes 1524, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Av Prof Lineu Prestes 1524, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENDOCRINE; v. 59, n. 1, p. 191-202, JAN 2018.
• Citações Web of Science: 2

Resumo

Hypothyroidism and thyrotoxicosis produce adverse effects in male reproduction by unknown mechanisms. We investigated whether triiodothyronine (T3) modulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) synthesis/secretion, by inducing different thyroid states. In hypothyroidism, the content of Lhb and Fshb mRNAs was increased, while their association to ribosomes and the protein content were reduced and the serum LH and FSH concentrations were augmented and decreased, respectively. Thyrotoxicosis reduced Lhb mRNA and LH serum concentration, and increased Lhb mRNA translational rate. The Fshb mRNA content and its association to ribosomes were also increased, whereas FSH serum concentrations were comparable to euthyroid levels. Acute T3 treatment decreased the total content of Lhb and Fshb mRNAs, and increased their association to ribosomes, as well as the LHB and FSHB contents in secretory granules. This study shows that T3 acts on gonadotrophs, resulting in direct effects on LH and FSH synthesis/secretion of male rats, suggesting that some reproductive disorders observed in men may be associated with thyroid hormone imbalances. (AU)

• Processo FAPESP: 09/17822-8 - Repercussões do tratamento com hormônio tiroideano em marcadores moleculares da função gonadal
• Beneficiário: Maria Tereza Nunes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/05629-4 - Ações genômicas vs não genômicas dos hormônios tiroidianos: mudanças de paradigmas, implicações fisiológicas e perspectivas terapêuticas
• Beneficiário: Maria Tereza Nunes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 08/50977-2 - Influencia do hormonio tiroideano na atividade do gonadotrofo.
• Beneficiário: Renata Marino Romano
• Modalidade de apoio: Bolsas no Brasil - Doutorado